STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
sucDsuccinyl-CoA synthetase alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (288 aa)    
Predicted Functional Partners:
sucC
succinyl-CoA synthetase beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 0.999
SFH27236.1
succinyl-CoA synthetase beta subunit.
 0.999
SFH27412.1
Succinate dehydrogenase / fumarate reductase iron-sulfur subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
 0.981
SFG66218.1
Fumarate reductase iron-sulfur subunit.
 
 0.973
SFH27425.1
Fumarate reductase flavoprotein subunit.
 0.959
SFG66249.1
Fumarate reductase flavoprotein subunit.
 0.955
SFG66281.1
Succinate dehydrogenase subunit C.
  
 
 0.943
SFH27386.1
Succinate dehydrogenase subunit C.
  
 
 0.943
SFG46131.1
methylmalonyl-CoA mutase, N-terminal domain.
    
 0.929
mdh
Malate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.
  
 0.926
Your Current Organism:
Desulfallas arcticus
NCBI taxonomy Id: 341036
Other names: D. arcticus, DSM 17038, Desulfallas arcticus (Vandieken et al. 2006) Watanabe et al. 2018, Desulfotomaculum arcticum, Desulfotomaculum arcticum Vandieken et al. 2006, JCM 12923, low G+C Gram-positive bacterium 15, strain 15
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