SFH24859.1 protein (Desulfallas arcticus) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

SFH24859.1

Maltodextrin phosphorylase. (849 aa)

Predicted Functional Partners:

SFG97796.1

0.976

SFG97818.1

0.954

SFG75685.1

0.940

SFH24894.1

0.932

SFF97039.1

0.879

SFG35093.1

0.850

eno

0.813

SFF97314.1

0.803

SFF97084.1

0.800

SFH07285.1

0.799

Your Current Organism:

Desulfallas arcticus

NCBI taxonomy Id: 341036
Other names: D. arcticus, DSM 17038, Desulfallas arcticus (Vandieken et al. 2006) Watanabe et al. 2018, Desulfotomaculum arcticum, Desulfotomaculum arcticum Vandieken et al. 2006, JCM 12923, low G+C Gram-positive bacterium 15, strain 15

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SFF97039.1	SFF97084.1	SAMN05660649_00262	SAMN05660649_00264	Nucleotidyltransferase.	1,4-alpha-glucan branching enzyme; Belongs to the glycosyl hydrolase 57 family.	0.771
SFF97039.1	SFF97314.1	SAMN05660649_00262	SAMN05660649_00275	Nucleotidyltransferase.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.762
SFF97039.1	SFG35093.1	SAMN05660649_00262	SAMN05660649_01377	Nucleotidyltransferase.	Nucleotidyl transferase.	0.931
SFF97039.1	SFG75685.1	SAMN05660649_00262	SAMN05660649_02583	Nucleotidyltransferase.	4-alpha-glucanotransferase.	0.872
SFF97039.1	SFG97796.1	SAMN05660649_00262	SAMN05660649_03361	Nucleotidyltransferase.	Maltooligosyltrehalose trehalohydrolase.	0.879
SFF97039.1	SFG97818.1	SAMN05660649_00262	SAMN05660649_03362	Nucleotidyltransferase.	1,4-alpha-glucan branching enzyme; Belongs to the glycosyl hydrolase 13 family.	0.879
SFF97039.1	SFH07285.1	SAMN05660649_00262	SAMN05660649_03755	Nucleotidyltransferase.	Phosphomannomutase.	0.773
SFF97039.1	SFH24859.1	SAMN05660649_00262	SAMN05660649_04411	Nucleotidyltransferase.	Maltodextrin phosphorylase.	0.879
SFF97039.1	SFH24894.1	SAMN05660649_00262	SAMN05660649_04413	Nucleotidyltransferase.	1,4-alpha-glucan branching enzyme; Belongs to the glycosyl hydrolase 57 family.	0.965
SFF97039.1	eno	SAMN05660649_00262	SAMN05660649_02171	Nucleotidyltransferase.	Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.	0.506
SFF97084.1	SFF97039.1	SAMN05660649_00264	SAMN05660649_00262	1,4-alpha-glucan branching enzyme; Belongs to the glycosyl hydrolase 57 family.	Nucleotidyltransferase.	0.771
SFF97084.1	SFG35093.1	SAMN05660649_00264	SAMN05660649_01377	1,4-alpha-glucan branching enzyme; Belongs to the glycosyl hydrolase 57 family.	Nucleotidyl transferase.	0.655
SFF97084.1	SFG75685.1	SAMN05660649_00264	SAMN05660649_02583	1,4-alpha-glucan branching enzyme; Belongs to the glycosyl hydrolase 57 family.	4-alpha-glucanotransferase.	0.865
SFF97084.1	SFG97796.1	SAMN05660649_00264	SAMN05660649_03361	1,4-alpha-glucan branching enzyme; Belongs to the glycosyl hydrolase 57 family.	Maltooligosyltrehalose trehalohydrolase.	0.871
SFF97084.1	SFG97818.1	SAMN05660649_00264	SAMN05660649_03362	1,4-alpha-glucan branching enzyme; Belongs to the glycosyl hydrolase 57 family.	1,4-alpha-glucan branching enzyme; Belongs to the glycosyl hydrolase 13 family.	0.674
SFF97084.1	SFH24859.1	SAMN05660649_00264	SAMN05660649_04411	1,4-alpha-glucan branching enzyme; Belongs to the glycosyl hydrolase 57 family.	Maltodextrin phosphorylase.	0.800
SFF97084.1	SFH24894.1	SAMN05660649_00264	SAMN05660649_04413	1,4-alpha-glucan branching enzyme; Belongs to the glycosyl hydrolase 57 family.	1,4-alpha-glucan branching enzyme; Belongs to the glycosyl hydrolase 57 family.	0.856
SFF97314.1	SFF97039.1	SAMN05660649_00275	SAMN05660649_00262	Pyruvate kinase; Belongs to the pyruvate kinase family.	Nucleotidyltransferase.	0.762
SFF97314.1	SFG35093.1	SAMN05660649_00275	SAMN05660649_01377	Pyruvate kinase; Belongs to the pyruvate kinase family.	Nucleotidyl transferase.	0.762
SFF97314.1	SFG75685.1	SAMN05660649_00275	SAMN05660649_02583	Pyruvate kinase; Belongs to the pyruvate kinase family.	4-alpha-glucanotransferase.	0.482

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

40

average node degree:

7.27

avg. local clustering coefficient:

0.848

expected number of edges:

11

PPI enrichment p-value:

5.84e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0044205

De novo UMP biosynthetic process

3 of 3

3.26

2.54

2.61e-05

GO:0006225

UDP biosynthetic process

3 of 4

3.14

2.53

2.61e-05

GO:0006207

De novo pyrimidine nucleobase biosynthetic process

3 of 6

2.96

2.52

2.61e-05

GO:0009156

Ribonucleoside monophosphate biosynthetic process

4 of 36

2.31

2.38

2.61e-05

GO:0016126

Sterol biosynthetic process

3 of 36

2.18

1.77

0.00039

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004128

cytochrome-b5 reductase activity, acting on NAD(P)H

5 of 5

3.26

5.97

1.24e-11

GO:0071949

FAD binding

4 of 41

2.25

2.69

5.25e-06

GO:0004151

Dihydroorotase activity

2 of 2

3.26

1.75

0.00069

GO:0016491

Oxidoreductase activity

7 of 847

1.18

1.26

4.01e-05

GO:0016884

Carbon-nitrogen ligase activity, with glutamine as amido-N-donor

2 of 10

2.56

1.22

0.0059

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:34822617

(2021) Suspected Drinking Water Poisoning in a Domestic Kitten with Methemoglobinemia.

5 of 5

3.26

5.28

2.39e-10

PMID:32039242

(2019) Methemoglobin Modulation as an Intravascular Contrast Agent for Magnetic Resonance Imaging: Proof of Concept.

5 of 5

3.26

5.28

2.39e-10

PMID:12030383

(2002) Methemoglobin reductase activity and in vitro sensitivity towards oxidant induced methemoglobinemia in swiss mice and beagle dogs erythrocytes.

5 of 5

3.26

5.28

2.39e-10

PMID:35202847

(2022) Oral Methylene Blue Treatment in A Dog with Cytochrome B5 Reductase Deficiency And 78, XX Testicular Disorder of Sex Development.

5 of 6

3.18

5.26

2.39e-10

PMID:22135611

(2011) Body weight reducing effect of oral boric acid intake.

5 of 6

3.18

5.26

2.39e-10

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:6070

Mixed, incl. cytochrome-b5 reductase activity, acting on NAD(P)H, and Amidohydrolase family

7 of 21

2.79

7.36

6.43e-15

CL:6072

Mixed, incl. L-ascorbic acid transmembrane transport, and Pyrimidine biosynthesis

4 of 12

2.79

3.71

1.30e-07

CL:6100

Nitric-oxide synthase complex, and cytochrome-b5 reductase activity, acting on NAD(P)H

3 of 6

2.96

2.71

1.13e-05

CL:6075

Mixed, incl. Pyrimidine biosynthesis, and Pyrimidine catabolism

3 of 7

2.9

2.67

1.30e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

cfa00520

Amino sugar and nucleotide sugar metabolism

5 of 42

2.34

4.02

8.29e-09

cfa00983

Drug metabolism - other enzymes

2 of 41

1.95

0.74

0.0399

cfa00240

Pyrimidine metabolism

2 of 42

1.94

0.74

0.0399

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

CFA-1237044

Erythrocytes take up carbon dioxide and release oxygen

4 of 10

2.87

3.85

7.59e-08

CFA-8956320

Nucleotide biosynthesis

4 of 12

2.79

3.83

7.59e-08

CFA-500753

Pyrimidine biosynthesis

3 of 3

3.26

3.32

9.59e-07

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0285

Flavoprotein

6 of 68

2.21

4.42

3.68e-10

KW-0274

FAD

5 of 61

2.18

3.61

2.98e-08

KW-0520

NAD

4 of 91

1.91

2.25

1.52e-05

KW-0560

Oxidoreductase

5 of 234

1.59

1.93

1.33e-05

KW-0315

Glutamine amidotransferase

2 of 6

2.79

1.76

0.00062

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00175

Oxidoreductase NAD-binding domain

6 of 11

3.0

6.89

1.38e-13

PF00970

Oxidoreductase FAD-binding domain

5 of 5

3.26

6.19

4.75e-12

PF00117

Glutamine amidotransferase class-I

2 of 3

3.09

1.48

0.0021

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