STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gedIProbable decarboxylase gedI; Probable decarboxylase; part of the gene cluster that mediates the biosynthesis of geodin, an intermediate in the biosynthesis of other natural products. The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase (PKS) gedC. The atrochrysone carboxyl ACP thioesterase gedB then breaks the thioester bond and releases the atrochrysone carboxylic acid from gedC. The atrochrysone carboxylic acid is then converted to atrochrysone which is further transformed into emodin anthrone. The next step is performed by the emodinanthrone oxy [...] (313 aa)    
Predicted Functional Partners:
gedH
Anthrone oxygenase gedH; Anthrone oxygenase; part of the gene cluster that mediates the biosynthesis of geodin, an intermediate in the biosynthesis of other natural products. The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase (PKS) gedC. The atrochrysone carboxyl ACP thioesterase gedB then breaks the thioester bond and releases the atrochrysone carboxylic acid from gedC. The atrochrysone carboxylic acid is then converted to atrochrysone which is further transformed into emodin anthrone. The next step is performed by the emodin anthrone oxygenase [...]
      
 0.806
ATEG_07591
Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.
   
 0.717
ATEG_07590
Uncharacterized protein.
   
 0.717
ATEG_05261
MFS domain-containing protein.
   
 0.717
ATEG_07720
Tryptophan synthase.
  
 
 0.716
ATEG_06425
Tryptophan synthase.
  
 
 0.716
ATEG_01301
Tryptophan synthase.
  
 
 0.716
ATEG_06305
Deoxyribose-phosphate aldolase.
  
 0.705
gedE
Glutathione S-transferase-like protein gedE; Glutathione S-transferase-like protein; part of the gene cluster that mediates the biosynthesis of geodin, an intermediate in the biosynthesis of other natural products. The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase (PKS) gedC. The atrochrysone carboxyl ACP thioesterase gedB then breaks the thioester bond and releases the atrochrysone carboxylic acid from gedC. The atrochrysone carboxylic acid is then converted to atrochrysone which is further transformed into emodinanthrone. The next step is perf [...]
     
 0.686
gedC
Atrochrysone carboxylic acid synthase; Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of geodin, an intermediate in the biosynthesis of other natural products. The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase (PKS) gedC. The atrochrysone carboxyl ACP thioesterase gedB then breaks the thioester bond and releases the atrochrysone carboxylic acid from gedC. The atrochrysone carboxylic acid is then converted to atrochrysone which is further transformed into emodinanthrone. The next step is performed by the [...]
      
 0.686
Your Current Organism:
Aspergillus terreus
NCBI taxonomy Id: 341663
Other names: A. terreus NIH2624, Aspergillus terreus FGSC A1156, Aspergillus terreus NIH2624
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