Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
kgdAlpha-ketoglutarate decarboxylase; Kgd; produces succinic semialdehyde; part of alternative pathway from alpha-ketoglutarate to succinate; essential for normal growth; Derived by automated computational analysis using gene prediction method: Protein Homology. (1238 aa)    
Predicted Functional Partners:
sucC
succinate--CoA ligase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 
 0.999
sucD
succinate--CoA ligase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
 
 0.999
lpdA
Dihydrolipoyl dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.997
ORA00925.1
Alpha-ketoacid dehydrogenase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.995
ORA01180.1
NAD(P)H-quinone dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.989
OQZ98616.1
NAD(P)(+) transhydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.989
atpA
ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.
  
 0.989
OQZ99328.1
Type II citrate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family.
 
 0.988
ORA00011.1
Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.987
OQZ92519.1
Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.987
Your Current Organism:
Mycolicibacter arupensis
NCBI taxonomy Id: 342002
Other names: DSM 44942, M. arupensis, Mycobacterium arupense, Mycobacterium arupense Cloud et al. 2006, Mycolicibacter arupensis (Cloud et al. 2006) Gupta et al. 2018, strain AR30097
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