| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| amb0022 | amb0023 | amb0022 | amb0023 | Predicted enzyme with a TIM-barrel fold; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. | Thiamine monophosphate synthase. | 0.660 |
| amb0022 | amb0593 | amb0022 | amb0593 | Predicted enzyme with a TIM-barrel fold; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. | Uncharacterized conserved protein; Belongs to the multicopper oxidase YfiH/RL5 family. | 0.773 |
| amb0022 | amb3949 | amb0022 | amb3949 | Predicted enzyme with a TIM-barrel fold; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. | Pyridoxal/pyridoxine/pyridoxamine kinase. | 0.695 |
| amb0022 | amb4376 | amb0022 | amb4376 | Predicted enzyme with a TIM-barrel fold; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. | Predicted integral membrane protein. | 0.734 |
| amb0022 | murF | amb0022 | amb3844 | Predicted enzyme with a TIM-barrel fold; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. | UDP-N-acetylmuramyl pentapeptide synthase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. | 0.625 |
| amb0022 | proC | amb0022 | amb0545 | Predicted enzyme with a TIM-barrel fold; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. | 0.715 |
| amb0022 | rlmN | amb0022 | amb1124 | Predicted enzyme with a TIM-barrel fold; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. | Predicted Fe-S-cluster redox enzyme; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. | 0.649 |
| amb0022 | rplX | amb0022 | amb3119 | Predicted enzyme with a TIM-barrel fold; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. | Ribosomal protein L24; One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. | 0.579 |
| amb0022 | rpmC | amb0022 | amb3122 | Predicted enzyme with a TIM-barrel fold; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. | Ribosomal protein L29; Belongs to the universal ribosomal protein uL29 family. | 0.587 |
| amb0022 | rpmJ | amb0022 | amb2294 | Predicted enzyme with a TIM-barrel fold; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. | Ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family. | 0.583 |
| amb0023 | amb0022 | amb0023 | amb0022 | Thiamine monophosphate synthase. | Predicted enzyme with a TIM-barrel fold; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. | 0.660 |
| amb0593 | amb0022 | amb0593 | amb0022 | Uncharacterized conserved protein; Belongs to the multicopper oxidase YfiH/RL5 family. | Predicted enzyme with a TIM-barrel fold; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. | 0.773 |
| amb3949 | amb0022 | amb3949 | amb0022 | Pyridoxal/pyridoxine/pyridoxamine kinase. | Predicted enzyme with a TIM-barrel fold; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. | 0.695 |
| amb4376 | amb0022 | amb4376 | amb0022 | Predicted integral membrane protein. | Predicted enzyme with a TIM-barrel fold; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. | 0.734 |
| amb4376 | proC | amb4376 | amb0545 | Predicted integral membrane protein. | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. | 0.433 |
| murF | amb0022 | amb3844 | amb0022 | UDP-N-acetylmuramyl pentapeptide synthase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. | Predicted enzyme with a TIM-barrel fold; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. | 0.625 |
| proC | amb0022 | amb0545 | amb0022 | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. | Predicted enzyme with a TIM-barrel fold; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. | 0.715 |
| proC | amb4376 | amb0545 | amb4376 | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. | Predicted integral membrane protein. | 0.433 |
| rlmN | amb0022 | amb1124 | amb0022 | Predicted Fe-S-cluster redox enzyme; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. | Predicted enzyme with a TIM-barrel fold; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. | 0.649 |
| rplX | amb0022 | amb3119 | amb0022 | Ribosomal protein L24; One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. | Predicted enzyme with a TIM-barrel fold; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. | 0.579 |