| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| amb0298 | amb0429 | amb0298 | amb0429 | Precorrin-3B methylase. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.617 |
| amb0298 | amb0541 | amb0298 | amb0541 | Precorrin-3B methylase. | Fructose-2,6-bisphosphatase. | 0.578 |
| amb0298 | amb2641 | amb0298 | amb2641 | Precorrin-3B methylase. | Precorrin-6x reductase. | 0.993 |
| amb0298 | amb3812 | amb0298 | amb3812 | Precorrin-3B methylase. | Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | 0.598 |
| amb0298 | amb4425 | amb0298 | amb4425 | Precorrin-3B methylase. | Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | 0.807 |
| amb0298 | cobD | amb0298 | amb0293 | Precorrin-3B methylase. | Cobalamin biosynthesis protein CobD/CbiB; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.918 |
| amb0298 | cobQ | amb0298 | amb0292 | Precorrin-3B methylase. | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.995 |
| amb0298 | cobT | amb0298 | amb0542 | Precorrin-3B methylase. | NaMN:DMB phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | 0.903 |
| amb0429 | amb0298 | amb0429 | amb0298 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Precorrin-3B methylase. | 0.617 |
| amb0429 | amb0521 | amb0429 | amb0521 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glutamate synthase [NADPH] large chain precursor. | 0.642 |
| amb0429 | amb0541 | amb0429 | amb0541 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Fructose-2,6-bisphosphatase. | 0.414 |
| amb0429 | amb3812 | amb0429 | amb3812 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | 0.435 |
| amb0429 | amb4425 | amb0429 | amb4425 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | 0.570 |
| amb0429 | cobD | amb0429 | amb0293 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Cobalamin biosynthesis protein CobD/CbiB; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.439 |
| amb0429 | cobQ | amb0429 | amb0292 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.481 |
| amb0429 | cobT | amb0429 | amb0542 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | NaMN:DMB phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | 0.619 |
| amb0521 | amb0429 | amb0521 | amb0429 | Glutamate synthase [NADPH] large chain precursor. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.642 |
| amb0521 | amb0541 | amb0521 | amb0541 | Glutamate synthase [NADPH] large chain precursor. | Fructose-2,6-bisphosphatase. | 0.499 |
| amb0541 | amb0298 | amb0541 | amb0298 | Fructose-2,6-bisphosphatase. | Precorrin-3B methylase. | 0.578 |
| amb0541 | amb0429 | amb0541 | amb0429 | Fructose-2,6-bisphosphatase. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.414 |