| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ahcY | amb0429 | amb4391 | amb0429 | S-adenosylhomocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.957 |
| ahcY | amb1294 | amb4391 | amb1294 | S-adenosylhomocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | Cystathionine beta-lyase/cystathionine gamma-synthase. | 0.924 |
| ahcY | amb1847 | amb4391 | amb1847 | S-adenosylhomocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | Cystathionine beta-lyase. | 0.951 |
| ahcY | amb2562 | amb4391 | amb2562 | S-adenosylhomocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | O-acetylhomoserine sulfhydrylase. | 0.916 |
| ahcY | amb3728 | amb4391 | amb3728 | S-adenosylhomocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | Homoserine dehydrogenase. | 0.834 |
| ahcY | metZ | amb4391 | amb4225 | S-adenosylhomocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | Cystathionine beta-lyase/cystathionine gamma-synthase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.944 |
| ahcY | thrB | amb4391 | amb0763 | S-adenosylhomocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | Homoserine kinase; Belongs to the pseudomonas-type ThrB family. | 0.806 |
| amb0429 | ahcY | amb0429 | amb4391 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | S-adenosylhomocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.957 |
| amb0429 | amb1294 | amb0429 | amb1294 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Cystathionine beta-lyase/cystathionine gamma-synthase. | 0.979 |
| amb0429 | amb1847 | amb0429 | amb1847 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Cystathionine beta-lyase. | 0.951 |
| amb0429 | amb2562 | amb0429 | amb2562 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | O-acetylhomoserine sulfhydrylase. | 0.959 |
| amb0429 | amb3388 | amb0429 | amb3388 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Threonine synthase. | 0.603 |
| amb0429 | amb3728 | amb0429 | amb3728 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Homoserine dehydrogenase. | 0.949 |
| amb0429 | ilvE | amb0429 | amb0551 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.577 |
| amb0429 | metZ | amb0429 | amb4225 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Cystathionine beta-lyase/cystathionine gamma-synthase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.979 |
| amb0429 | thrB | amb0429 | amb0763 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Homoserine kinase; Belongs to the pseudomonas-type ThrB family. | 0.816 |
| amb1294 | ahcY | amb1294 | amb4391 | Cystathionine beta-lyase/cystathionine gamma-synthase. | S-adenosylhomocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.924 |
| amb1294 | amb0429 | amb1294 | amb0429 | Cystathionine beta-lyase/cystathionine gamma-synthase. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.979 |
| amb1294 | amb1847 | amb1294 | amb1847 | Cystathionine beta-lyase/cystathionine gamma-synthase. | Cystathionine beta-lyase. | 0.994 |
| amb1294 | amb2562 | amb1294 | amb2562 | Cystathionine beta-lyase/cystathionine gamma-synthase. | O-acetylhomoserine sulfhydrylase. | 0.950 |