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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
mamETrypsin-like serine protease, typically periplasmic; Acts at 2 distinct steps of magnetosome formation; required for correct localization of proteins to the magnetosome while the protease activity is required for maturation of small magnetite crystals into larger, functional ones. The 2 functions are separable by mutation. Probably cleaves at least itself, MamO and MamP; cleavage requires the putative transport domain of MamO (Probable). Involved in localization of some proteins (at least MamA, MamC, MamF, MamI and MamJ) to the magnetosome. (728 aa)    
Predicted Functional Partners:
mamH
Permease of the major facilitator superfamily; Required for correct biomineralization of the magnetosome; probably transports some form of iron. Partially functionally redundant with MamZ; Belongs to the major facilitator superfamily.
 
   
 0.911
mamI
Hypothetical protein; Essential for magnetosome formation. May bind magnetite (Probable). May be involved in an early stage of magnetosome nucleation (By similarity).
     
 0.905
mamK
Actin-like ATPase; Protein with ATPase activity which forms dynamic cytoplasmic filaments (probably with paralog MamK-like) that organize magnetosomes into long chains running parallel to the long axis of the cell (Probable). Turnover of MamK filaments is probably promoted by MamK-like, which provides a monomer pool. Forms twisted filaments in the presence of ATP or GTP. Serves to close gaps between magnetosomes in the chain. Interaction with MCP10 is involved in controlling the response to magnetic fields, possibly by controlling flagellar rotation. Expression in E.coli yields a filam [...]
 
   
 0.897
mamJ
Periplasmic protein TonB; Regulates the dynamic behavior of MamK filaments; paralog LimJ also promotes MamK turnover. At least one other protein besides MamJ and LimJ is required for MamK turnover. May connect magnetosomes to MamK filaments (Probable). Moves from the cell poles towards midcell; movement does not depend on the treadmilling ability of MamK, suggesting MamJ associates and disassociates continuously from the MamK filament (By similarity).
     
 0.814
mamM
Predicted Co/Zn/Cd cation transporters; Probably plays a role in biomineralization (Probable). Required for stable accumulation of MamB (By similarity). Probably binds and transports iron. May nucleate iron crystal formation (By similarity); Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family.
 
   
 0.806
mamN
Na+/H+ antiporter NhaD and related arsenite permease; Plays a role in biomineralization; might regulate pH in the magnetosome; Belongs to the arsenite-antimonite (ArsB) efflux (TC 2.A.45) family.
 
   
 0.803
amb1708
Trypsin-like serine protease; Typically periplasmic, contain C-terminal PDZ domain.
  
 
 0.777
mamL
Hypothetical protein; Essential for magnetosome formation. Belongs to the magnetosome MamL family.
     
 0.764
mamB
Predicted Co/Zn/Cd cation transporters; Plays a dual, essential role in magnetosome formation; required for magnetosome vesicle formation as well as biomineralization (Probable). Probably binds and transports iron (By similarity). Requires heterodimerization with MamM for stability (By similarity); Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family.
 
   
 0.752
mamP
Hypothetical protein; Involved in redox-control of magnetite formation; oxidizes Fe(2+) to Fe(3+) or to mixed-valent Fe(2+)-Fe(3+) oxide minerals. May control magnetite crystal size and number (Probable). Overproduction of MamP leads to more crystals than normal during exponential growth of normal size; in stationary phase crystal numbers become wild-type.
     
 0.742
Your Current Organism:
Magnetospirillum magneticum
NCBI taxonomy Id: 342108
Other names: M. magneticum AMB-1, Magnetospirillum magneticum AMB-1, Magnetospirillum magneticum str. AMB-1, Magnetospirillum magneticum strain AMB-1, Magnetospirillum sp. (strain AMB-1), Magnetospirillum sp. AMB-1
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