| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| amb0602 | mamE | amb0602 | amb0963 | Outer membrane protein and related peptidoglycan-associated protein. | Trypsin-like serine protease, typically periplasmic; Acts at 2 distinct steps of magnetosome formation; required for correct localization of proteins to the magnetosome while the protease activity is required for maturation of small magnetite crystals into larger, functional ones. The 2 functions are separable by mutation. Probably cleaves at least itself, MamO and MamP; cleavage requires the putative transport domain of MamO (Probable). Involved in localization of some proteins (at least MamA, MamC, MamF, MamI and MamJ) to the magnetosome. | 0.654 |
| amb0602 | mamJ | amb0602 | amb0964 | Outer membrane protein and related peptidoglycan-associated protein. | Periplasmic protein TonB; Regulates the dynamic behavior of MamK filaments; paralog LimJ also promotes MamK turnover. At least one other protein besides MamJ and LimJ is required for MamK turnover. May connect magnetosomes to MamK filaments (Probable). Moves from the cell poles towards midcell; movement does not depend on the treadmilling ability of MamK, suggesting MamJ associates and disassociates continuously from the MamK filament (By similarity). | 0.421 |
| amb0602 | rplD | amb0602 | amb3129 | Outer membrane protein and related peptidoglycan-associated protein. | Ribosomal protein L4; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. | 0.805 |
| amb0602 | rplX | amb0602 | amb3119 | Outer membrane protein and related peptidoglycan-associated protein. | Ribosomal protein L24; One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. | 0.831 |
| mamE | amb0602 | amb0963 | amb0602 | Trypsin-like serine protease, typically periplasmic; Acts at 2 distinct steps of magnetosome formation; required for correct localization of proteins to the magnetosome while the protease activity is required for maturation of small magnetite crystals into larger, functional ones. The 2 functions are separable by mutation. Probably cleaves at least itself, MamO and MamP; cleavage requires the putative transport domain of MamO (Probable). Involved in localization of some proteins (at least MamA, MamC, MamF, MamI and MamJ) to the magnetosome. | Outer membrane protein and related peptidoglycan-associated protein. | 0.654 |
| mamE | mamH | amb0963 | amb0961 | Trypsin-like serine protease, typically periplasmic; Acts at 2 distinct steps of magnetosome formation; required for correct localization of proteins to the magnetosome while the protease activity is required for maturation of small magnetite crystals into larger, functional ones. The 2 functions are separable by mutation. Probably cleaves at least itself, MamO and MamP; cleavage requires the putative transport domain of MamO (Probable). Involved in localization of some proteins (at least MamA, MamC, MamF, MamI and MamJ) to the magnetosome. | Permease of the major facilitator superfamily; Required for correct biomineralization of the magnetosome; probably transports some form of iron. Partially functionally redundant with MamZ; Belongs to the major facilitator superfamily. | 0.911 |
| mamE | mamI | amb0963 | amb0962 | Trypsin-like serine protease, typically periplasmic; Acts at 2 distinct steps of magnetosome formation; required for correct localization of proteins to the magnetosome while the protease activity is required for maturation of small magnetite crystals into larger, functional ones. The 2 functions are separable by mutation. Probably cleaves at least itself, MamO and MamP; cleavage requires the putative transport domain of MamO (Probable). Involved in localization of some proteins (at least MamA, MamC, MamF, MamI and MamJ) to the magnetosome. | Hypothetical protein; Essential for magnetosome formation. May bind magnetite (Probable). May be involved in an early stage of magnetosome nucleation (By similarity). | 0.905 |
| mamE | mamJ | amb0963 | amb0964 | Trypsin-like serine protease, typically periplasmic; Acts at 2 distinct steps of magnetosome formation; required for correct localization of proteins to the magnetosome while the protease activity is required for maturation of small magnetite crystals into larger, functional ones. The 2 functions are separable by mutation. Probably cleaves at least itself, MamO and MamP; cleavage requires the putative transport domain of MamO (Probable). Involved in localization of some proteins (at least MamA, MamC, MamF, MamI and MamJ) to the magnetosome. | Periplasmic protein TonB; Regulates the dynamic behavior of MamK filaments; paralog LimJ also promotes MamK turnover. At least one other protein besides MamJ and LimJ is required for MamK turnover. May connect magnetosomes to MamK filaments (Probable). Moves from the cell poles towards midcell; movement does not depend on the treadmilling ability of MamK, suggesting MamJ associates and disassociates continuously from the MamK filament (By similarity). | 0.814 |
| mamE | mamK | amb0963 | amb0965 | Trypsin-like serine protease, typically periplasmic; Acts at 2 distinct steps of magnetosome formation; required for correct localization of proteins to the magnetosome while the protease activity is required for maturation of small magnetite crystals into larger, functional ones. The 2 functions are separable by mutation. Probably cleaves at least itself, MamO and MamP; cleavage requires the putative transport domain of MamO (Probable). Involved in localization of some proteins (at least MamA, MamC, MamF, MamI and MamJ) to the magnetosome. | Actin-like ATPase; Protein with ATPase activity which forms dynamic cytoplasmic filaments (probably with paralog MamK-like) that organize magnetosomes into long chains running parallel to the long axis of the cell (Probable). Turnover of MamK filaments is probably promoted by MamK-like, which provides a monomer pool. Forms twisted filaments in the presence of ATP or GTP. Serves to close gaps between magnetosomes in the chain. Interaction with MCP10 is involved in controlling the response to magnetic fields, possibly by controlling flagellar rotation. Expression in E.coli yields a filam [...] | 0.897 |
| mamE | mamL | amb0963 | amb0966 | Trypsin-like serine protease, typically periplasmic; Acts at 2 distinct steps of magnetosome formation; required for correct localization of proteins to the magnetosome while the protease activity is required for maturation of small magnetite crystals into larger, functional ones. The 2 functions are separable by mutation. Probably cleaves at least itself, MamO and MamP; cleavage requires the putative transport domain of MamO (Probable). Involved in localization of some proteins (at least MamA, MamC, MamF, MamI and MamJ) to the magnetosome. | Hypothetical protein; Essential for magnetosome formation. Belongs to the magnetosome MamL family. | 0.764 |
| mamE | mamM | amb0963 | amb0967 | Trypsin-like serine protease, typically periplasmic; Acts at 2 distinct steps of magnetosome formation; required for correct localization of proteins to the magnetosome while the protease activity is required for maturation of small magnetite crystals into larger, functional ones. The 2 functions are separable by mutation. Probably cleaves at least itself, MamO and MamP; cleavage requires the putative transport domain of MamO (Probable). Involved in localization of some proteins (at least MamA, MamC, MamF, MamI and MamJ) to the magnetosome. | Predicted Co/Zn/Cd cation transporters; Probably plays a role in biomineralization (Probable). Required for stable accumulation of MamB (By similarity). Probably binds and transports iron. May nucleate iron crystal formation (By similarity); Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. | 0.806 |
| mamE | mms24 | amb0963 | amb0971 | Trypsin-like serine protease, typically periplasmic; Acts at 2 distinct steps of magnetosome formation; required for correct localization of proteins to the magnetosome while the protease activity is required for maturation of small magnetite crystals into larger, functional ones. The 2 functions are separable by mutation. Probably cleaves at least itself, MamO and MamP; cleavage requires the putative transport domain of MamO (Probable). Involved in localization of some proteins (at least MamA, MamC, MamF, MamI and MamJ) to the magnetosome. | TPR repeat; Probably forms a large homooligomer on which other magnetosome subunits assemble (Probable). Required for formation of functional magnetosomes from pre-existing vesicles, it has a dynamic location in the cell. | 0.586 |
| mamH | mamE | amb0961 | amb0963 | Permease of the major facilitator superfamily; Required for correct biomineralization of the magnetosome; probably transports some form of iron. Partially functionally redundant with MamZ; Belongs to the major facilitator superfamily. | Trypsin-like serine protease, typically periplasmic; Acts at 2 distinct steps of magnetosome formation; required for correct localization of proteins to the magnetosome while the protease activity is required for maturation of small magnetite crystals into larger, functional ones. The 2 functions are separable by mutation. Probably cleaves at least itself, MamO and MamP; cleavage requires the putative transport domain of MamO (Probable). Involved in localization of some proteins (at least MamA, MamC, MamF, MamI and MamJ) to the magnetosome. | 0.911 |
| mamH | mamI | amb0961 | amb0962 | Permease of the major facilitator superfamily; Required for correct biomineralization of the magnetosome; probably transports some form of iron. Partially functionally redundant with MamZ; Belongs to the major facilitator superfamily. | Hypothetical protein; Essential for magnetosome formation. May bind magnetite (Probable). May be involved in an early stage of magnetosome nucleation (By similarity). | 0.860 |
| mamH | mamJ | amb0961 | amb0964 | Permease of the major facilitator superfamily; Required for correct biomineralization of the magnetosome; probably transports some form of iron. Partially functionally redundant with MamZ; Belongs to the major facilitator superfamily. | Periplasmic protein TonB; Regulates the dynamic behavior of MamK filaments; paralog LimJ also promotes MamK turnover. At least one other protein besides MamJ and LimJ is required for MamK turnover. May connect magnetosomes to MamK filaments (Probable). Moves from the cell poles towards midcell; movement does not depend on the treadmilling ability of MamK, suggesting MamJ associates and disassociates continuously from the MamK filament (By similarity). | 0.618 |
| mamH | mamK | amb0961 | amb0965 | Permease of the major facilitator superfamily; Required for correct biomineralization of the magnetosome; probably transports some form of iron. Partially functionally redundant with MamZ; Belongs to the major facilitator superfamily. | Actin-like ATPase; Protein with ATPase activity which forms dynamic cytoplasmic filaments (probably with paralog MamK-like) that organize magnetosomes into long chains running parallel to the long axis of the cell (Probable). Turnover of MamK filaments is probably promoted by MamK-like, which provides a monomer pool. Forms twisted filaments in the presence of ATP or GTP. Serves to close gaps between magnetosomes in the chain. Interaction with MCP10 is involved in controlling the response to magnetic fields, possibly by controlling flagellar rotation. Expression in E.coli yields a filam [...] | 0.927 |
| mamH | mamL | amb0961 | amb0966 | Permease of the major facilitator superfamily; Required for correct biomineralization of the magnetosome; probably transports some form of iron. Partially functionally redundant with MamZ; Belongs to the major facilitator superfamily. | Hypothetical protein; Essential for magnetosome formation. Belongs to the magnetosome MamL family. | 0.435 |
| mamH | mamM | amb0961 | amb0967 | Permease of the major facilitator superfamily; Required for correct biomineralization of the magnetosome; probably transports some form of iron. Partially functionally redundant with MamZ; Belongs to the major facilitator superfamily. | Predicted Co/Zn/Cd cation transporters; Probably plays a role in biomineralization (Probable). Required for stable accumulation of MamB (By similarity). Probably binds and transports iron. May nucleate iron crystal formation (By similarity); Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. | 0.841 |
| mamH | mms24 | amb0961 | amb0971 | Permease of the major facilitator superfamily; Required for correct biomineralization of the magnetosome; probably transports some form of iron. Partially functionally redundant with MamZ; Belongs to the major facilitator superfamily. | TPR repeat; Probably forms a large homooligomer on which other magnetosome subunits assemble (Probable). Required for formation of functional magnetosomes from pre-existing vesicles, it has a dynamic location in the cell. | 0.650 |
| mamI | mamE | amb0962 | amb0963 | Hypothetical protein; Essential for magnetosome formation. May bind magnetite (Probable). May be involved in an early stage of magnetosome nucleation (By similarity). | Trypsin-like serine protease, typically periplasmic; Acts at 2 distinct steps of magnetosome formation; required for correct localization of proteins to the magnetosome while the protease activity is required for maturation of small magnetite crystals into larger, functional ones. The 2 functions are separable by mutation. Probably cleaves at least itself, MamO and MamP; cleavage requires the putative transport domain of MamO (Probable). Involved in localization of some proteins (at least MamA, MamC, MamF, MamI and MamJ) to the magnetosome. | 0.905 |