STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
mamQ1Uncharacterized conserved protein; Essential for magnetosome formation. Can be used to induce magnetosome formation. (296 aa)    
Predicted Functional Partners:
mamO
Trypsin-like serine protease; Plays 2 roles; promotes magnetite nucleation/formation and activates the MamE protease (Probable). Despite its near conservation of a protease-like sequence, this is probably not a protease (Probable). Required in conjunction with MamP for proteolysis of at least MamE, itself and MamP. May transport a solute that controls MamE's protease activity. May place individual iron atoms into the magnetite lattice (Probable). In the N-terminal section; belongs to the peptidase S1C family.
 
   
 0.856
mamB
Predicted Co/Zn/Cd cation transporters; Plays a dual, essential role in magnetosome formation; required for magnetosome vesicle formation as well as biomineralization (Probable). Probably binds and transports iron (By similarity). Requires heterodimerization with MamM for stability (By similarity); Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family.
 
   
 0.816
mamR
Hypothetical protein; May play a role in controlling magnetite number and size but not in control of magnetite morphology; Belongs to the magnetosome MamR family.
     
 0.776
mms24
TPR repeat; Probably forms a large homooligomer on which other magnetosome subunits assemble (Probable). Required for formation of functional magnetosomes from pre-existing vesicles, it has a dynamic location in the cell.
       0.773
mamS
Hypothetical protein; May play a role in magnetite crystal growth and size. Belongs to the magnetosome MamS family.
     
 0.752
mamP
Hypothetical protein; Involved in redox-control of magnetite formation; oxidizes Fe(2+) to Fe(3+) or to mixed-valent Fe(2+)-Fe(3+) oxide minerals. May control magnetite crystal size and number (Probable). Overproduction of MamP leads to more crystals than normal during exponential growth of normal size; in stationary phase crystal numbers become wild-type.
     
 0.739
mamT
Hypothetical protein; May play a role in magnetite crystal maturation (Probable). May transfer electrons to balance the Fe(2+)-Fe(3+) ratio during magnetite formation (Probable).
     
 0.680
mamM
Predicted Co/Zn/Cd cation transporters; Probably plays a role in biomineralization (Probable). Required for stable accumulation of MamB (By similarity). Probably binds and transports iron. May nucleate iron crystal formation (By similarity); Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family.
 
   
 0.655
mamK
Actin-like ATPase; Protein with ATPase activity which forms dynamic cytoplasmic filaments (probably with paralog MamK-like) that organize magnetosomes into long chains running parallel to the long axis of the cell (Probable). Turnover of MamK filaments is probably promoted by MamK-like, which provides a monomer pool. Forms twisted filaments in the presence of ATP or GTP. Serves to close gaps between magnetosomes in the chain. Interaction with MCP10 is involved in controlling the response to magnetic fields, possibly by controlling flagellar rotation. Expression in E.coli yields a filam [...]
 
  
 0.549
mamU
Sphingosine kinase and enzyme; Might phosphorylate lipids; Belongs to the diacylglycerol/lipid kinase family.
       0.534
Your Current Organism:
Magnetospirillum magneticum
NCBI taxonomy Id: 342108
Other names: M. magneticum AMB-1, Magnetospirillum magneticum AMB-1, Magnetospirillum magneticum str. AMB-1, Magnetospirillum magneticum strain AMB-1, Magnetospirillum sp. (strain AMB-1), Magnetospirillum sp. AMB-1
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