STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mamUSphingosine kinase and enzyme; Might phosphorylate lipids; Belongs to the diacylglycerol/lipid kinase family. (297 aa)    
Predicted Functional Partners:
amb2503
Predicted phosphohydrolase.
 
   
 0.802
mamR
Hypothetical protein; May play a role in controlling magnetite number and size but not in control of magnetite morphology; Belongs to the magnetosome MamR family.
     
 0.795
mamV
Predicted Co/Zn/Cd cation transporters; Expression of just the minimal mamAB gene cluster (amb0961 to amb0978), including this gene, is sufficient to form a minimal magnetosome chain with small magnetite particles.
     
 0.686
mamT
Hypothetical protein; May play a role in magnetite crystal maturation (Probable). May transfer electrons to balance the Fe(2+)-Fe(3+) ratio during magnetite formation (Probable).
       0.620
mamS
Hypothetical protein; May play a role in magnetite crystal growth and size. Belongs to the magnetosome MamS family.
       0.575
mamQ1
Uncharacterized conserved protein; Essential for magnetosome formation. Can be used to induce magnetosome formation.
     
 0.554
mamB
Predicted Co/Zn/Cd cation transporters; Plays a dual, essential role in magnetosome formation; required for magnetosome vesicle formation as well as biomineralization (Probable). Probably binds and transports iron (By similarity). Requires heterodimerization with MamM for stability (By similarity); Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family.
     
 0.554
mamP
Hypothetical protein; Involved in redox-control of magnetite formation; oxidizes Fe(2+) to Fe(3+) or to mixed-valent Fe(2+)-Fe(3+) oxide minerals. May control magnetite crystal size and number (Probable). Overproduction of MamP leads to more crystals than normal during exponential growth of normal size; in stationary phase crystal numbers become wild-type.
   
 
 0.546
mms24
TPR repeat; Probably forms a large homooligomer on which other magnetosome subunits assemble (Probable). Required for formation of functional magnetosomes from pre-existing vesicles, it has a dynamic location in the cell.
     
 0.540
mamO
Trypsin-like serine protease; Plays 2 roles; promotes magnetite nucleation/formation and activates the MamE protease (Probable). Despite its near conservation of a protease-like sequence, this is probably not a protease (Probable). Required in conjunction with MamP for proteolysis of at least MamE, itself and MamP. May transport a solute that controls MamE's protease activity. May place individual iron atoms into the magnetite lattice (Probable). In the N-terminal section; belongs to the peptidase S1C family.
   
 
 0.529
Your Current Organism:
Magnetospirillum magneticum
NCBI taxonomy Id: 342108
Other names: M. magneticum AMB-1, Magnetospirillum magneticum AMB-1, Magnetospirillum magneticum str. AMB-1, Magnetospirillum magneticum strain AMB-1, Magnetospirillum sp. (strain AMB-1), Magnetospirillum sp. AMB-1
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