STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
mamVPredicted Co/Zn/Cd cation transporters; Expression of just the minimal mamAB gene cluster (amb0961 to amb0978), including this gene, is sufficient to form a minimal magnetosome chain with small magnetite particles. (333 aa)    
Predicted Functional Partners:
mamU
Sphingosine kinase and enzyme; Might phosphorylate lipids; Belongs to the diacylglycerol/lipid kinase family.
     
 0.612
mdh
Malate/lactate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.
  
    0.582
mamM
Predicted Co/Zn/Cd cation transporters; Probably plays a role in biomineralization (Probable). Required for stable accumulation of MamB (By similarity). Probably binds and transports iron. May nucleate iron crystal formation (By similarity); Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family.
 
   
0.511
mamQ1
Uncharacterized conserved protein; Essential for magnetosome formation. Can be used to induce magnetosome formation.
 
   
 0.488
mms24
TPR repeat; Probably forms a large homooligomer on which other magnetosome subunits assemble (Probable). Required for formation of functional magnetosomes from pre-existing vesicles, it has a dynamic location in the cell.
 
     0.465
mamO
Trypsin-like serine protease; Plays 2 roles; promotes magnetite nucleation/formation and activates the MamE protease (Probable). Despite its near conservation of a protease-like sequence, this is probably not a protease (Probable). Required in conjunction with MamP for proteolysis of at least MamE, itself and MamP. May transport a solute that controls MamE's protease activity. May place individual iron atoms into the magnetite lattice (Probable). In the N-terminal section; belongs to the peptidase S1C family.
     
 0.458
mamB
Predicted Co/Zn/Cd cation transporters; Plays a dual, essential role in magnetosome formation; required for magnetosome vesicle formation as well as biomineralization (Probable). Probably binds and transports iron (By similarity). Requires heterodimerization with MamM for stability (By similarity); Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family.
 
    
0.458
mamT
Hypothetical protein; May play a role in magnetite crystal maturation (Probable). May transfer electrons to balance the Fe(2+)-Fe(3+) ratio during magnetite formation (Probable).
     
 0.455
mamS
Hypothetical protein; May play a role in magnetite crystal growth and size. Belongs to the magnetosome MamS family.
     
 0.445
mamN
Na+/H+ antiporter NhaD and related arsenite permease; Plays a role in biomineralization; might regulate pH in the magnetosome; Belongs to the arsenite-antimonite (ArsB) efflux (TC 2.A.45) family.
 
   
 0.433
Your Current Organism:
Magnetospirillum magneticum
NCBI taxonomy Id: 342108
Other names: M. magneticum AMB-1, Magnetospirillum magneticum AMB-1, Magnetospirillum magneticum str. AMB-1, Magnetospirillum magneticum strain AMB-1, Magnetospirillum sp. (strain AMB-1), Magnetospirillum sp. AMB-1
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