STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mamVPredicted Co/Zn/Cd cation transporters; Expression of just the minimal mamAB gene cluster (amb0961 to amb0978), including this gene, is sufficient to form a minimal magnetosome chain with small magnetite particles. (333 aa)    
Predicted Functional Partners:
mamU
Sphingosine kinase and enzyme; Might phosphorylate lipids; Belongs to the diacylglycerol/lipid kinase family.
     
 0.686
mamO
Trypsin-like serine protease; Plays 2 roles; promotes magnetite nucleation/formation and activates the MamE protease (Probable). Despite its near conservation of a protease-like sequence, this is probably not a protease (Probable). Required in conjunction with MamP for proteolysis of at least MamE, itself and MamP. May transport a solute that controls MamE's protease activity. May place individual iron atoms into the magnetite lattice (Probable). In the N-terminal section; belongs to the peptidase S1C family.
     
 0.610
mdh
Malate/lactate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.
  
    0.585
mamQ1
Uncharacterized conserved protein; Essential for magnetosome formation. Can be used to induce magnetosome formation.
 
   
 0.563
mamT
Hypothetical protein; May play a role in magnetite crystal maturation (Probable). May transfer electrons to balance the Fe(2+)-Fe(3+) ratio during magnetite formation (Probable).
     
 0.557
mamM
Predicted Co/Zn/Cd cation transporters; Probably plays a role in biomineralization (Probable). Required for stable accumulation of MamB (By similarity). Probably binds and transports iron. May nucleate iron crystal formation (By similarity); Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family.
 
   
0.541
mamN
Na+/H+ antiporter NhaD and related arsenite permease; Plays a role in biomineralization; might regulate pH in the magnetosome; Belongs to the arsenite-antimonite (ArsB) efflux (TC 2.A.45) family.
 
   
 0.537
mamS
Hypothetical protein; May play a role in magnetite crystal growth and size. Belongs to the magnetosome MamS family.
     
 0.522
mamH
Permease of the major facilitator superfamily; Required for correct biomineralization of the magnetosome; probably transports some form of iron. Partially functionally redundant with MamZ; Belongs to the major facilitator superfamily.
 
   
 0.514
mamK
Actin-like ATPase; Protein with ATPase activity which forms dynamic cytoplasmic filaments (probably with paralog MamK-like) that organize magnetosomes into long chains running parallel to the long axis of the cell (Probable). Turnover of MamK filaments is probably promoted by MamK-like, which provides a monomer pool. Forms twisted filaments in the presence of ATP or GTP. Serves to close gaps between magnetosomes in the chain. Interaction with MCP10 is involved in controlling the response to magnetic fields, possibly by controlling flagellar rotation. Expression in E.coli yields a filam [...]
     
 0.501
Your Current Organism:
Magnetospirillum magneticum
NCBI taxonomy Id: 342108
Other names: M. magneticum AMB-1, Magnetospirillum magneticum AMB-1, Magnetospirillum magneticum str. AMB-1, Magnetospirillum magneticum strain AMB-1, Magnetospirillum sp. (strain AMB-1), Magnetospirillum sp. AMB-1
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