STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mamZPermease of the major facilitator superfamily; Required for correct biomineralization of the magnetosome; probably converts and then transports some form of iron. It is partially functionally redundant with MamH. May function with MamX, MamY amd Mms6. (644 aa)    
Predicted Functional Partners:
msrP
Sulfite oxidase and related enzyme; Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce bot [...]
 
  
 0.953
mamX
Hypothetical protein; Required for correct biomineralization of the magnetosome, may be involved in redox control of biomineralization. May function with MamY, MamZ amd Mms6.
     
 0.918
ftsZ
Cell division GTPase; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
     
 0.852
mamY
Methyl-accepting chemotaxis protein; Causes tubulation when added to magnetosome-derived liposomes, binds liposomes; may be involved in constriction of the cell inner membrane to form mature magnetosomes. Binds preferentially to cardiolipin, a component of bacterial membranes, with very poor to no binding of other tested (phospho)lipids. Addition of cardiolipin to magnetosome-derived lipids increases tubulation. May function with MamX, MamZ amd Mms6 (By similarity).
     
 0.776
amb2545
Sulfite oxidase and related enzyme.
  
  
 0.721
mamE
Trypsin-like serine protease, typically periplasmic; Acts at 2 distinct steps of magnetosome formation; required for correct localization of proteins to the magnetosome while the protease activity is required for maturation of small magnetite crystals into larger, functional ones. The 2 functions are separable by mutation. Probably cleaves at least itself, MamO and MamP; cleavage requires the putative transport domain of MamO (Probable). Involved in localization of some proteins (at least MamA, MamC, MamF, MamI and MamJ) to the magnetosome.
  
   
 0.681
mamB
Predicted Co/Zn/Cd cation transporters; Plays a dual, essential role in magnetosome formation; required for magnetosome vesicle formation as well as biomineralization (Probable). Probably binds and transports iron (By similarity). Requires heterodimerization with MamM for stability (By similarity); Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family.
 
   
 0.678
mamO
Trypsin-like serine protease; Plays 2 roles; promotes magnetite nucleation/formation and activates the MamE protease (Probable). Despite its near conservation of a protease-like sequence, this is probably not a protease (Probable). Required in conjunction with MamP for proteolysis of at least MamE, itself and MamP. May transport a solute that controls MamE's protease activity. May place individual iron atoms into the magnetite lattice (Probable). In the N-terminal section; belongs to the peptidase S1C family.
  
  
 0.637
mms6
Bacterial magnetic particle specific iron-binding protein; Promotes the formation of magnetite in Fe(2+)-rich conditions, when magnetite is not readily formed. Binds Fe(3+) and Fe(2+) (Probable). May play a role in nucleation of magnetite crystal formation (Probable). May help control production of crystals with a specific morphology (Probable). Greatly improves the formation of magnetosome-like magnetite crystals in vitro. Isolated short protein, probably residues 75-133, binds up to 18 Fe(3+) per monomer and self-assembles into micelles about 21-26 nm in diameter; the C-terminal 21 [...]
      
 0.579
amb0410
Hypothetical protein.
  
   
 0.562
Your Current Organism:
Magnetospirillum magneticum
NCBI taxonomy Id: 342108
Other names: M. magneticum AMB-1, Magnetospirillum magneticum AMB-1, Magnetospirillum magneticum str. AMB-1, Magnetospirillum magneticum strain AMB-1, Magnetospirillum sp. (strain AMB-1), Magnetospirillum sp. AMB-1
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