| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ahcY | amb0429 | amb4391 | amb0429 | S-adenosylhomocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.973 |
| ahcY | amb1294 | amb4391 | amb1294 | S-adenosylhomocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | Cystathionine beta-lyase/cystathionine gamma-synthase. | 0.926 |
| ahcY | amb1847 | amb4391 | amb1847 | S-adenosylhomocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | Cystathionine beta-lyase. | 0.941 |
| ahcY | amb2562 | amb4391 | amb2562 | S-adenosylhomocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | O-acetylhomoserine sulfhydrylase. | 0.918 |
| ahcY | cysC | amb4391 | amb2212 | S-adenosylhomocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | NodQ bifunctional enzyme; Catalyzes the synthesis of activated sulfate. | 0.441 |
| ahcY | glyA | amb4391 | amb2339 | S-adenosylhomocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.659 |
| ahcY | metZ | amb4391 | amb4225 | S-adenosylhomocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | Cystathionine beta-lyase/cystathionine gamma-synthase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.945 |
| amb0429 | ahcY | amb0429 | amb4391 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | S-adenosylhomocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.973 |
| amb0429 | amb1294 | amb0429 | amb1294 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Cystathionine beta-lyase/cystathionine gamma-synthase. | 0.982 |
| amb0429 | amb1847 | amb0429 | amb1847 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Cystathionine beta-lyase. | 0.948 |
| amb0429 | amb2562 | amb0429 | amb2562 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | O-acetylhomoserine sulfhydrylase. | 0.970 |
| amb0429 | amb3479 | amb0429 | amb3479 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Phosphoserine phosphatase. | 0.444 |
| amb0429 | cysC | amb0429 | amb2212 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | NodQ bifunctional enzyme; Catalyzes the synthesis of activated sulfate. | 0.743 |
| amb0429 | glyA | amb0429 | amb2339 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.959 |
| amb0429 | metZ | amb0429 | amb4225 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Cystathionine beta-lyase/cystathionine gamma-synthase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.982 |
| amb1294 | ahcY | amb1294 | amb4391 | Cystathionine beta-lyase/cystathionine gamma-synthase. | S-adenosylhomocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.926 |
| amb1294 | amb0429 | amb1294 | amb0429 | Cystathionine beta-lyase/cystathionine gamma-synthase. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.982 |
| amb1294 | amb1847 | amb1294 | amb1847 | Cystathionine beta-lyase/cystathionine gamma-synthase. | Cystathionine beta-lyase. | 0.992 |
| amb1294 | amb1852 | amb1294 | amb1852 | Cystathionine beta-lyase/cystathionine gamma-synthase. | Serine acetyltransferase. | 0.421 |
| amb1294 | amb2562 | amb1294 | amb2562 | Cystathionine beta-lyase/cystathionine gamma-synthase. | O-acetylhomoserine sulfhydrylase. | 0.949 |