| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| amb0012 | amb0771 | amb0012 | amb0771 | 2-polyprenyl-6-methoxyphenol hydroxylase; Related FAD-dependent oxidoreductase. | 4-hydroxybenzoate polyprenyltransferase and related prenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | 0.572 |
| amb0012 | amb2323 | amb0012 | amb2323 | 2-polyprenyl-6-methoxyphenol hydroxylase; Related FAD-dependent oxidoreductase. | Oligoketide cyclase/lipid transport protein. | 0.505 |
| amb0012 | ubiE | amb0012 | amb0631 | 2-polyprenyl-6-methoxyphenol hydroxylase; Related FAD-dependent oxidoreductase. | Methylase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). | 0.930 |
| amb0012 | ubiG | amb0012 | amb1611 | 2-polyprenyl-6-methoxyphenol hydroxylase; Related FAD-dependent oxidoreductase. | 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family. | 0.974 |
| amb0771 | amb0012 | amb0771 | amb0012 | 4-hydroxybenzoate polyprenyltransferase and related prenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | 2-polyprenyl-6-methoxyphenol hydroxylase; Related FAD-dependent oxidoreductase. | 0.572 |
| amb0771 | amb2323 | amb0771 | amb2323 | 4-hydroxybenzoate polyprenyltransferase and related prenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | Oligoketide cyclase/lipid transport protein. | 0.608 |
| amb0771 | ubiE | amb0771 | amb0631 | 4-hydroxybenzoate polyprenyltransferase and related prenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | Methylase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). | 0.665 |
| amb0771 | ubiG | amb0771 | amb1611 | 4-hydroxybenzoate polyprenyltransferase and related prenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family. | 0.757 |
| amb2317 | amb2318 | amb2317 | amb2318 | Pyruvate dehydrogenase E1 component, beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.999 |
| amb2317 | amb2321 | amb2317 | amb2321 | Pyruvate dehydrogenase E1 component, beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzyme. | 0.999 |
| amb2317 | amb2323 | amb2317 | amb2323 | Pyruvate dehydrogenase E1 component, beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | Oligoketide cyclase/lipid transport protein. | 0.506 |
| amb2317 | lipA | amb2317 | amb2322 | Pyruvate dehydrogenase E1 component, beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | Lipoate synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.662 |
| amb2317 | pdhA | amb2317 | amb2316 | Pyruvate dehydrogenase E1 component, beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.999 |
| amb2318 | amb2317 | amb2318 | amb2317 | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Pyruvate dehydrogenase E1 component, beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.999 |
| amb2318 | amb2321 | amb2318 | amb2321 | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzyme. | 0.999 |
| amb2318 | amb2323 | amb2318 | amb2323 | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Oligoketide cyclase/lipid transport protein. | 0.517 |
| amb2318 | lipA | amb2318 | amb2322 | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Lipoate synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.786 |
| amb2318 | pdhA | amb2318 | amb2316 | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.999 |
| amb2321 | amb2317 | amb2321 | amb2317 | Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzyme. | Pyruvate dehydrogenase E1 component, beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.999 |
| amb2321 | amb2318 | amb2321 | amb2318 | Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzyme. | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.999 |