| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| amb0766 | amb0769 | amb0766 | amb0769 | Glycine cleavage system T protein. | Glycine cleavage system protein P; (pyridoxal-binding), C-terminal domain. | 0.999 |
| amb0766 | folD | amb0766 | amb4374 | Glycine cleavage system T protein. | 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.971 |
| amb0766 | gcvH | amb0766 | amb0767 | Glycine cleavage system T protein. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.999 |
| amb0766 | gcvPA | amb0766 | amb0768 | Glycine cleavage system T protein. | Glycine cleavage system protein P; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.999 |
| amb0766 | glyA | amb0766 | amb2339 | Glycine cleavage system T protein. | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.998 |
| amb0766 | purH | amb0766 | amb0100 | Glycine cleavage system T protein. | AICAR transformylase; Only IMP cyclohydrolase domain in Aful. | 0.949 |
| amb0766 | purN | amb0766 | amb2847 | Glycine cleavage system T protein. | Folate-dependent phosphoribosylglycinamide formyltransferase PurN; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.939 |
| amb0769 | amb0766 | amb0769 | amb0766 | Glycine cleavage system protein P; (pyridoxal-binding), C-terminal domain. | Glycine cleavage system T protein. | 0.999 |
| amb0769 | folD | amb0769 | amb4374 | Glycine cleavage system protein P; (pyridoxal-binding), C-terminal domain. | 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.969 |
| amb0769 | gcvH | amb0769 | amb0767 | Glycine cleavage system protein P; (pyridoxal-binding), C-terminal domain. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.999 |
| amb0769 | gcvPA | amb0769 | amb0768 | Glycine cleavage system protein P; (pyridoxal-binding), C-terminal domain. | Glycine cleavage system protein P; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.999 |
| amb0769 | glyA | amb0769 | amb2339 | Glycine cleavage system protein P; (pyridoxal-binding), C-terminal domain. | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.986 |
| amb0769 | purH | amb0769 | amb0100 | Glycine cleavage system protein P; (pyridoxal-binding), C-terminal domain. | AICAR transformylase; Only IMP cyclohydrolase domain in Aful. | 0.623 |
| amb1847 | amb3479 | amb1847 | amb3479 | Cystathionine beta-lyase. | Phosphoserine phosphatase. | 0.923 |
| amb1847 | glyA | amb1847 | amb2339 | Cystathionine beta-lyase. | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.959 |
| amb2338 | glyA | amb2338 | amb2339 | Ribose 5-phosphate isomerase RpiB. | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.984 |
| amb3479 | amb1847 | amb3479 | amb1847 | Phosphoserine phosphatase. | Cystathionine beta-lyase. | 0.923 |
| amb3479 | glyA | amb3479 | amb2339 | Phosphoserine phosphatase. | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.946 |
| folD | amb0766 | amb4374 | amb0766 | 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine cleavage system T protein. | 0.971 |
| folD | amb0769 | amb4374 | amb0769 | 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine cleavage system protein P; (pyridoxal-binding), C-terminal domain. | 0.969 |
