| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| adk | amb2392 | amb3110 | amb2392 | Adenylate kinase and related kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Predicted pyrophosphatase. | 0.915 |
| adk | pyrG | amb3110 | amb1821 | Adenylate kinase and related kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.445 |
| adk | thyA | amb3110 | amb1327 | Adenylate kinase and related kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.423 |
| adk | tmk | amb3110 | amb2450 | Adenylate kinase and related kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.441 |
| amb1697 | amb2253 | amb1697 | amb2253 | Guanosine polyphosphate pyrophosphohydrolase/synthetase. | Guanosine polyphosphate pyrophosphohydrolase/synthetase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.920 |
| amb1697 | amb2392 | amb1697 | amb2392 | Guanosine polyphosphate pyrophosphohydrolase/synthetase. | Predicted pyrophosphatase. | 0.920 |
| amb2253 | amb1697 | amb2253 | amb1697 | Guanosine polyphosphate pyrophosphohydrolase/synthetase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | Guanosine polyphosphate pyrophosphohydrolase/synthetase. | 0.920 |
| amb2253 | amb2392 | amb2253 | amb2392 | Guanosine polyphosphate pyrophosphohydrolase/synthetase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | Predicted pyrophosphatase. | 0.920 |
| amb2392 | adk | amb2392 | amb3110 | Predicted pyrophosphatase. | Adenylate kinase and related kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.915 |
| amb2392 | amb1697 | amb2392 | amb1697 | Predicted pyrophosphatase. | Guanosine polyphosphate pyrophosphohydrolase/synthetase. | 0.920 |
| amb2392 | amb2253 | amb2392 | amb2253 | Predicted pyrophosphatase. | Guanosine polyphosphate pyrophosphohydrolase/synthetase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.920 |
| amb2392 | amb2693 | amb2392 | amb2693 | Predicted pyrophosphatase. | NTP pyrophosphohydrolase; Zn-finger, probably nucleic-acid-binding. | 0.911 |
| amb2392 | amb2738 | amb2392 | amb2738 | Predicted pyrophosphatase. | Nicotinic acid phosphoribosyltransferase; Belongs to the NAPRTase family. | 0.916 |
| amb2392 | cmk | amb2392 | amb4262 | Predicted pyrophosphatase. | Cytidylate kinase. | 0.910 |
| amb2392 | coaE | amb2392 | amb4546 | Predicted pyrophosphatase. | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | 0.908 |
| amb2392 | pyrG | amb2392 | amb1821 | Predicted pyrophosphatase. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.915 |
| amb2392 | thyA | amb2392 | amb1327 | Predicted pyrophosphatase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.932 |
| amb2392 | tmk | amb2392 | amb2450 | Predicted pyrophosphatase. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.922 |
| amb2693 | amb2392 | amb2693 | amb2392 | NTP pyrophosphohydrolase; Zn-finger, probably nucleic-acid-binding. | Predicted pyrophosphatase. | 0.911 |
| amb2693 | amb2738 | amb2693 | amb2738 | NTP pyrophosphohydrolase; Zn-finger, probably nucleic-acid-binding. | Nicotinic acid phosphoribosyltransferase; Belongs to the NAPRTase family. | 0.912 |