| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| amb0429 | amb3812 | amb0429 | amb3812 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | 0.435 |
| amb0429 | amb3905 | amb0429 | amb3905 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Uncharacterized conserved protein; Belongs to the Cob(I)alamin adenosyltransferase family. | 0.729 |
| amb0429 | amb4425 | amb0429 | amb4425 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | 0.570 |
| amb0429 | amb4427 | amb0429 | amb4427 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Cobalamin biosynthesis protein CobN and related Mg-chelatase. | 0.574 |
| amb0429 | amb4475 | amb0429 | amb4475 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | ATP:corrinoid adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. | 0.637 |
| amb0429 | cobD | amb0429 | amb0293 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Cobalamin biosynthesis protein CobD/CbiB; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.439 |
| amb0429 | cobQ | amb0429 | amb0292 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.481 |
| amb3812 | amb0429 | amb3812 | amb0429 | Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.435 |
| amb3812 | amb3905 | amb3812 | amb3905 | Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | Uncharacterized conserved protein; Belongs to the Cob(I)alamin adenosyltransferase family. | 0.917 |
| amb3812 | amb4425 | amb3812 | amb4425 | Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | 0.979 |
| amb3812 | amb4475 | amb3812 | amb4475 | Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | ATP:corrinoid adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. | 0.960 |
| amb3812 | cbiA | amb3812 | amb3622 | Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.558 |
| amb3812 | cobD | amb3812 | amb0293 | Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | Cobalamin biosynthesis protein CobD/CbiB; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.983 |
| amb3812 | cobQ | amb3812 | amb0292 | Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.995 |
| amb3905 | amb0429 | amb3905 | amb0429 | Uncharacterized conserved protein; Belongs to the Cob(I)alamin adenosyltransferase family. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.729 |
| amb3905 | amb3812 | amb3905 | amb3812 | Uncharacterized conserved protein; Belongs to the Cob(I)alamin adenosyltransferase family. | Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | 0.917 |
| amb3905 | amb3915 | amb3905 | amb3915 | Uncharacterized conserved protein; Belongs to the Cob(I)alamin adenosyltransferase family. | CobS protein. | 0.900 |
| amb3905 | amb3916 | amb3905 | amb3916 | Uncharacterized conserved protein; Belongs to the Cob(I)alamin adenosyltransferase family. | CobT protein. | 0.902 |
| amb3905 | amb4425 | amb3905 | amb4425 | Uncharacterized conserved protein; Belongs to the Cob(I)alamin adenosyltransferase family. | Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | 0.927 |
| amb3905 | amb4427 | amb3905 | amb4427 | Uncharacterized conserved protein; Belongs to the Cob(I)alamin adenosyltransferase family. | Cobalamin biosynthesis protein CobN and related Mg-chelatase. | 0.922 |