| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| amb1368 | guaA | amb1368 | amb0732 | Nucleoside phosphorylase. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.592 |
| amb1368 | guaB | amb1368 | amb3781 | Nucleoside phosphorylase. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.529 |
| amb1368 | mtnP | amb1368 | amb4121 | Nucleoside phosphorylase. | Purine nucleoside phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. | 0.919 |
| amb1368 | nadE | amb1368 | amb1233 | Nucleoside phosphorylase. | Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.565 |
| amb1949 | amb2592 | amb1949 | amb2592 | Phenolpthiocerol synthesis polyketide synthase ppsA. | Esterase/lipase. | 0.955 |
| amb1949 | guaB | amb1949 | amb3781 | Phenolpthiocerol synthesis polyketide synthase ppsA. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.591 |
| amb1949 | mtnP | amb1949 | amb4121 | Phenolpthiocerol synthesis polyketide synthase ppsA. | Purine nucleoside phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. | 0.447 |
| amb1949 | nadE | amb1949 | amb1233 | Phenolpthiocerol synthesis polyketide synthase ppsA. | Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.739 |
| amb2592 | amb1949 | amb2592 | amb1949 | Esterase/lipase. | Phenolpthiocerol synthesis polyketide synthase ppsA. | 0.955 |
| amb2592 | mtnP | amb2592 | amb4121 | Esterase/lipase. | Purine nucleoside phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. | 0.740 |
| amb2592 | nadE | amb2592 | amb1233 | Esterase/lipase. | Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.502 |
| amb4120 | mtnP | amb4120 | amb4121 | Uncharacterized conserved protein. | Purine nucleoside phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. | 0.553 |
| apt | guaA | amb2849 | amb0732 | Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.995 |
| apt | guaB | amb2849 | amb3781 | Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.656 |
| apt | mtnA | amb2849 | amb4123 | Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Predicted translation initiation factor 2B subunit; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). | 0.762 |
| apt | mtnP | amb2849 | amb4121 | Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Purine nucleoside phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. | 0.966 |
| apt | nadE | amb2849 | amb1233 | Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.503 |
| guaA | amb1368 | amb0732 | amb1368 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Nucleoside phosphorylase. | 0.592 |
| guaA | apt | amb0732 | amb2849 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.995 |
| guaA | guaB | amb0732 | amb3781 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.999 |
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