| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| amb0429 | amb2456 | amb0429 | amb2456 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Related to diketogulonate reductase. | 0.576 |
| amb0429 | cbbM | amb0429 | amb2696 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Ribulose bisphosphate carboxylase large chain 2; RuBisCO catalyzes two reactions: the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site; Belongs to the RuBisCO large chain family. Type II subfamily. | 0.638 |
| amb0429 | mtnA | amb0429 | amb4123 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Predicted translation initiation factor 2B subunit; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). | 0.810 |
| amb0593 | apt | amb0593 | amb2849 | Uncharacterized conserved protein; Belongs to the multicopper oxidase YfiH/RL5 family. | Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.908 |
| amb0593 | mtnA | amb0593 | amb4123 | Uncharacterized conserved protein; Belongs to the multicopper oxidase YfiH/RL5 family. | Predicted translation initiation factor 2B subunit; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). | 0.903 |
| amb0593 | mtnP | amb0593 | amb4121 | Uncharacterized conserved protein; Belongs to the multicopper oxidase YfiH/RL5 family. | Purine nucleoside phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. | 0.905 |
| amb1379 | apt | amb1379 | amb2849 | Pentose-5-phosphate-3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. | Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.500 |
| amb1379 | ffh | amb1379 | amb4062 | Pentose-5-phosphate-3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. | Signal recognition particle GTPase; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual component [...] | 0.567 |
| amb1379 | mtnA | amb1379 | amb4123 | Pentose-5-phosphate-3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. | Predicted translation initiation factor 2B subunit; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). | 0.757 |
| amb2456 | amb0429 | amb2456 | amb0429 | Related to diketogulonate reductase. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.576 |
| amb2456 | mtnA | amb2456 | amb4123 | Related to diketogulonate reductase. | Predicted translation initiation factor 2B subunit; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). | 0.521 |
| amb4381 | mtnA | amb4381 | amb4123 | Phenylalanyl-tRNA synthetase alpha subunit. | Predicted translation initiation factor 2B subunit; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). | 0.566 |
| apt | amb0593 | amb2849 | amb0593 | Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Uncharacterized conserved protein; Belongs to the multicopper oxidase YfiH/RL5 family. | 0.908 |
| apt | amb1379 | amb2849 | amb1379 | Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Pentose-5-phosphate-3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. | 0.500 |
| apt | mtnA | amb2849 | amb4123 | Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Predicted translation initiation factor 2B subunit; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). | 0.795 |
| apt | mtnP | amb2849 | amb4121 | Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Purine nucleoside phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. | 0.963 |
| cbbM | amb0429 | amb2696 | amb0429 | Ribulose bisphosphate carboxylase large chain 2; RuBisCO catalyzes two reactions: the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site; Belongs to the RuBisCO large chain family. Type II subfamily. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.638 |
| cbbM | mtnA | amb2696 | amb4123 | Ribulose bisphosphate carboxylase large chain 2; RuBisCO catalyzes two reactions: the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site; Belongs to the RuBisCO large chain family. Type II subfamily. | Predicted translation initiation factor 2B subunit; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). | 0.576 |
| ffh | amb1379 | amb4062 | amb1379 | Signal recognition particle GTPase; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual component [...] | Pentose-5-phosphate-3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. | 0.567 |
| ffh | mtnA | amb4062 | amb4123 | Signal recognition particle GTPase; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual component [...] | Predicted translation initiation factor 2B subunit; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). | 0.480 |
