| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| dmlR_8 | msrC | DM82_2032 | DM82_2033 | Bacterial regulatory helix-turn-helix, lysR family protein; Belongs to the LysR transcriptional regulatory family. | GAF domain protein. | 0.482 |
| mdeA_1 | metE | DM82_5086 | DM82_2170 | Aminotransferase class I and II family protein. | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.961 |
| mdeA_1 | metH | DM82_5086 | DM82_3598 | Aminotransferase class I and II family protein. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.934 |
| mdeA_1 | metH_2 | DM82_5086 | DM82_3599 | Aminotransferase class I and II family protein. | Homocysteine S-methyltransferase family protein. | 0.952 |
| mdeA_1 | metK | DM82_5086 | DM82_3398 | Aminotransferase class I and II family protein. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.930 |
| mdeA_1 | msrC | DM82_5086 | DM82_2033 | Aminotransferase class I and II family protein. | GAF domain protein. | 0.902 |
| mdeA_1 | tyrB | DM82_5086 | DM82_4106 | Aminotransferase class I and II family protein. | Aromatic-amino-acid aminotransferase. | 0.907 |
| mdeA_1 | tyrB_1 | DM82_5086 | DM82_4930 | Aminotransferase class I and II family protein. | Aminotransferase class I and II family protein. | 0.907 |
| mdeA_1 | tyrB_3 | DM82_5086 | DM82_4454 | Aminotransferase class I and II family protein. | Aminotransferase class I and II family protein. | 0.907 |
| metE | mdeA_1 | DM82_2170 | DM82_5086 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | Aminotransferase class I and II family protein. | 0.961 |
| metE | metH | DM82_2170 | DM82_3598 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.932 |
| metE | metH_2 | DM82_2170 | DM82_3599 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | Homocysteine S-methyltransferase family protein. | 0.969 |
| metE | metK | DM82_2170 | DM82_3398 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.989 |
| metE | msrC | DM82_2170 | DM82_2033 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | GAF domain protein. | 0.900 |
| metE | tyrB | DM82_2170 | DM82_4106 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | Aromatic-amino-acid aminotransferase. | 0.907 |
| metE | tyrB_1 | DM82_2170 | DM82_4930 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | Aminotransferase class I and II family protein. | 0.907 |
| metE | tyrB_3 | DM82_2170 | DM82_4454 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | Aminotransferase class I and II family protein. | 0.907 |
| metH | mdeA_1 | DM82_3598 | DM82_5086 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Aminotransferase class I and II family protein. | 0.934 |
| metH | metE | DM82_3598 | DM82_2170 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.932 |
| metH | metH_2 | DM82_3598 | DM82_3599 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Homocysteine S-methyltransferase family protein. | 0.999 |