| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DM82_6205 | lepB | DM82_6205 | DM82_2050 | Metallo-beta-lactamase superfamily protein. | sigpep_I_bact: signal peptidase I; Belongs to the peptidase S26 family. | 0.701 |
| DM82_6205 | lepB-2 | DM82_6205 | DM82_5196 | Metallo-beta-lactamase superfamily protein. | sigpep_I_bact: signal peptidase I; Belongs to the peptidase S26 family. | 0.701 |
| DM82_6205 | mutS | DM82_6205 | DM82_1855 | Metallo-beta-lactamase superfamily protein. | DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. | 0.888 |
| lepA | lepB | DM82_2051 | DM82_2050 | GTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | sigpep_I_bact: signal peptidase I; Belongs to the peptidase S26 family. | 0.917 |
| lepA | lepB-2 | DM82_2051 | DM82_5196 | GTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | sigpep_I_bact: signal peptidase I; Belongs to the peptidase S26 family. | 0.932 |
| lepA | mucD_2 | DM82_2051 | DM82_2053 | GTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | degP_htrA_DO: peptidase Do family protein; Belongs to the peptidase S1C family. | 0.586 |
| lepA | rnc | DM82_2051 | DM82_2049 | GTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | Ribonuclease III; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. | 0.729 |
| lepA | secY | DM82_2051 | DM82_2895 | GTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | Preprotein translocase, SecY subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | 0.420 |
| lepA | yidC | DM82_2051 | DM82_3266 | GTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | Membrane protein insertase, YidC/Oxa1 family; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | 0.408 |
| lepB | DM82_6205 | DM82_2050 | DM82_6205 | sigpep_I_bact: signal peptidase I; Belongs to the peptidase S26 family. | Metallo-beta-lactamase superfamily protein. | 0.701 |
| lepB | lepA | DM82_2050 | DM82_2051 | sigpep_I_bact: signal peptidase I; Belongs to the peptidase S26 family. | GTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | 0.917 |
| lepB | lepB-2 | DM82_2050 | DM82_5196 | sigpep_I_bact: signal peptidase I; Belongs to the peptidase S26 family. | sigpep_I_bact: signal peptidase I; Belongs to the peptidase S26 family. | 0.943 |
| lepB | minE | DM82_2050 | DM82_2218 | sigpep_I_bact: signal peptidase I; Belongs to the peptidase S26 family. | Cell division topological specificity factor MinE; Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell. | 0.695 |
| lepB | mucD_2 | DM82_2050 | DM82_2053 | sigpep_I_bact: signal peptidase I; Belongs to the peptidase S26 family. | degP_htrA_DO: peptidase Do family protein; Belongs to the peptidase S1C family. | 0.668 |
| lepB | mutS | DM82_2050 | DM82_1855 | sigpep_I_bact: signal peptidase I; Belongs to the peptidase S26 family. | DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. | 0.723 |
| lepB | rnc | DM82_2050 | DM82_2049 | sigpep_I_bact: signal peptidase I; Belongs to the peptidase S26 family. | Ribonuclease III; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. | 0.763 |
| lepB | rseP | DM82_2050 | DM82_1736 | sigpep_I_bact: signal peptidase I; Belongs to the peptidase S26 family. | RIP metalloprotease RseP. | 0.748 |
| lepB | secY | DM82_2050 | DM82_2895 | sigpep_I_bact: signal peptidase I; Belongs to the peptidase S26 family. | Preprotein translocase, SecY subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | 0.740 |
| lepB | yidC | DM82_2050 | DM82_3266 | sigpep_I_bact: signal peptidase I; Belongs to the peptidase S26 family. | Membrane protein insertase, YidC/Oxa1 family; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | 0.716 |
| lepB-2 | DM82_6205 | DM82_5196 | DM82_6205 | sigpep_I_bact: signal peptidase I; Belongs to the peptidase S26 family. | Metallo-beta-lactamase superfamily protein. | 0.701 |