spoT protein (Burkholderia oklahomensis) - STRING interaction network

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spoT

RelA/SpoT family protein; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (788 aa)

Predicted Functional Partners:

gmk

0.963

ppx

0.927

ndk

0.925

pyk-3

0.922

pyk-2

0.920

relA

0.918

pyk

0.917

nrdA

0.909

rpsF

0.901

nrdE_1

0.901

Your Current Organism:

Burkholderia oklahomensis

NCBI taxonomy Id: 342113
Other names: B. oklahomensis, Burkholderia oklahomensis Glass et al. 2006, CCUG 51349, DSM 21774, LMG 23618, LMG:23618, NCTC 13387, strain C6786

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
gmk	ndk	DM82_2205	DM82_1495	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Nucleoside diphosphate kinase family protein; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	0.938
gmk	nrdA	DM82_2205	DM82_2656	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	0.923
gmk	nrdE_1	DM82_2205	DM82_4046	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Ribonucleotide reductase, barrel domain protein.	0.915
gmk	pyk	DM82_2205	DM82_139	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Pyruv_kin: pyruvate kinase; Belongs to the pyruvate kinase family.	0.936
gmk	pyk-2	DM82_2205	DM82_190	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Pyruv_kin: pyruvate kinase; Belongs to the pyruvate kinase family.	0.935
gmk	pyk-3	DM82_2205	DM82_3847	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Pyruv_kin: pyruvate kinase; Belongs to the pyruvate kinase family.	0.936
gmk	spoT	DM82_2205	DM82_2203	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	RelA/SpoT family protein; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.	0.963
ndk	gmk	DM82_1495	DM82_2205	Nucleoside diphosphate kinase family protein; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.938
ndk	nrdA	DM82_1495	DM82_2656	Nucleoside diphosphate kinase family protein; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	0.933
ndk	nrdE_1	DM82_1495	DM82_4046	Nucleoside diphosphate kinase family protein; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	Ribonucleotide reductase, barrel domain protein.	0.920
ndk	pyk	DM82_1495	DM82_139	Nucleoside diphosphate kinase family protein; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	Pyruv_kin: pyruvate kinase; Belongs to the pyruvate kinase family.	0.909
ndk	pyk-2	DM82_1495	DM82_190	Nucleoside diphosphate kinase family protein; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	Pyruv_kin: pyruvate kinase; Belongs to the pyruvate kinase family.	0.909
ndk	pyk-3	DM82_1495	DM82_3847	Nucleoside diphosphate kinase family protein; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	Pyruv_kin: pyruvate kinase; Belongs to the pyruvate kinase family.	0.909
ndk	relA	DM82_1495	DM82_998	Nucleoside diphosphate kinase family protein; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	RelA/SpoT family protein; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.	0.925
ndk	rpsF	DM82_1495	DM82_1559	Nucleoside diphosphate kinase family protein; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	Ribosomal protein S6; Binds together with S18 to 16S ribosomal RNA.	0.994
ndk	spoT	DM82_1495	DM82_2203	Nucleoside diphosphate kinase family protein; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	RelA/SpoT family protein; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.	0.925
nrdA	gmk	DM82_2656	DM82_2205	Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.923
nrdA	ndk	DM82_2656	DM82_1495	Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	Nucleoside diphosphate kinase family protein; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	0.933
nrdA	nrdE_1	DM82_2656	DM82_4046	Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	Ribonucleotide reductase, barrel domain protein.	0.927
nrdA	pyk	DM82_2656	DM82_139	Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	Pyruv_kin: pyruvate kinase; Belongs to the pyruvate kinase family.	0.905

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