hpt protein (Burkholderia oklahomensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

hpt

Phosphoribosyl transferase domain protein. (183 aa)

Predicted Functional Partners:

guaA

0.967

guaB

0.950

purA

0.946

gmk

0.941

purH

0.940

guaD

0.933

DM82_3156

0.930

yfiH

0.923

surE

0.920

add

0.920

Your Current Organism:

Burkholderia oklahomensis

NCBI taxonomy Id: 342113
Other names: B. oklahomensis, Burkholderia oklahomensis Glass et al. 2006, CCUG 51349, DSM 21774, LMG 23618, LMG:23618, NCTC 13387, strain C6786

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DM82_3156	gmk	DM82_3156	DM82_2205	Peptidase C26 family protein.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.926
DM82_3156	guaA	DM82_3156	DM82_1711	Peptidase C26 family protein.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.925
DM82_3156	guaB	DM82_3156	DM82_1713	Peptidase C26 family protein.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.972
DM82_3156	hpt	DM82_3156	DM82_2662	Peptidase C26 family protein.	Phosphoribosyl transferase domain protein.	0.930
DM82_3156	purA	DM82_3156	DM82_1481	Peptidase C26 family protein.	Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	0.552
DM82_3156	purH	DM82_3156	DM82_2566	Peptidase C26 family protein.	purH: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase.	0.460
DM82_3156	surE	DM82_3156	DM82_1503	Peptidase C26 family protein.	5'/3'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.	0.927
add	guaA	DM82_2164	DM82_1711	Adenosine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.717
add	guaB	DM82_2164	DM82_1713	Adenosine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.529
add	guaD	DM82_2164	DM82_2166	Adenosine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.	Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.	0.785
add	hpt	DM82_2164	DM82_2662	Adenosine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.	Phosphoribosyl transferase domain protein.	0.920
add	yfiH	DM82_2164	DM82_1471	Adenosine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.	Hypothetical protein; Belongs to the multicopper oxidase YfiH/RL5 family.	0.904
gmk	DM82_3156	DM82_2205	DM82_3156	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Peptidase C26 family protein.	0.926
gmk	guaA	DM82_2205	DM82_1711	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.970
gmk	guaB	DM82_2205	DM82_1713	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.528
gmk	hpt	DM82_2205	DM82_2662	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Phosphoribosyl transferase domain protein.	0.941
gmk	purA	DM82_2205	DM82_1481	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	0.520
gmk	surE	DM82_2205	DM82_1503	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	5'/3'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.	0.900
guaA	DM82_3156	DM82_1711	DM82_3156	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Peptidase C26 family protein.	0.925
guaA	add	DM82_1711	DM82_2164	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Adenosine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.	0.717

page 1 of 4

Server load: low (18%) [HD]

Permalink

Network

Neighborhood

Experiments

Co-occurrence

Databases

Co-expression

Textmining

Fusion

© STRING Consortium 2026

Credits

Access

Info

About