| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DM82_2828 | DM82_2829 | DM82_2828 | DM82_2829 | HIT domain protein. | Putative transmembrane protein. | 0.730 |
| DM82_2828 | grpE | DM82_2828 | DM82_2499 | HIT domain protein. | grpE family protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depe [...] | 0.498 |
| DM82_2828 | hisE | DM82_2828 | DM82_2830 | HIT domain protein. | histidine_hisI: phosphoribosyl-ATP diphosphatase. | 0.607 |
| DM82_2828 | hisF | DM82_2828 | DM82_2832 | HIT domain protein. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.607 |
| DM82_2828 | hisI | DM82_2828 | DM82_2831 | HIT domain protein. | phosphoribosyl-AMP cyclohydrolase family protein; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.609 |
| DM82_2828 | rpoA | DM82_2828 | DM82_2889 | HIT domain protein. | DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.475 |
| DM82_2828 | rpoC | DM82_2828 | DM82_2922 | HIT domain protein. | DNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.495 |
| DM82_2828 | tatA | DM82_2828 | DM82_2827 | HIT domain protein. | Twin arginine-targeting translocase, TatA/E family protein; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. | 0.672 |
| DM82_2828 | tatB | DM82_2828 | DM82_2826 | HIT domain protein. | Twin arginine-targeting protein translocase TatB; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation. | 0.631 |
| DM82_2828 | tatC | DM82_2828 | DM82_2825 | HIT domain protein. | Twin arginine-targeting protein translocase TatC; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides. | 0.507 |
| DM82_2829 | DM82_2828 | DM82_2829 | DM82_2828 | Putative transmembrane protein. | HIT domain protein. | 0.730 |
| DM82_2829 | hisE | DM82_2829 | DM82_2830 | Putative transmembrane protein. | histidine_hisI: phosphoribosyl-ATP diphosphatase. | 0.667 |
| DM82_2829 | hisF | DM82_2829 | DM82_2832 | Putative transmembrane protein. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.667 |
| DM82_2829 | hisI | DM82_2829 | DM82_2831 | Putative transmembrane protein. | phosphoribosyl-AMP cyclohydrolase family protein; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.667 |
| DM82_2829 | tatA | DM82_2829 | DM82_2827 | Putative transmembrane protein. | Twin arginine-targeting translocase, TatA/E family protein; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. | 0.563 |
| DM82_2829 | tatB | DM82_2829 | DM82_2826 | Putative transmembrane protein. | Twin arginine-targeting protein translocase TatB; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation. | 0.530 |
| DM82_2829 | tatC | DM82_2829 | DM82_2825 | Putative transmembrane protein. | Twin arginine-targeting protein translocase TatC; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides. | 0.477 |
| grpE | DM82_2828 | DM82_2499 | DM82_2828 | grpE family protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depe [...] | HIT domain protein. | 0.498 |
| grpE | rpoA | DM82_2499 | DM82_2889 | grpE family protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depe [...] | DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.433 |
| hisE | DM82_2828 | DM82_2830 | DM82_2828 | histidine_hisI: phosphoribosyl-ATP diphosphatase. | HIT domain protein. | 0.607 |