| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DM82_4657 | gcvP | DM82_4657 | DM82_3089 | Electron transfer flavodomain protein. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.922 |
| DM82_4657 | gcvT_2 | DM82_4657 | DM82_5560 | Electron transfer flavodomain protein. | soxA: sarcosine oxidase, alpha subunit; Belongs to the GcvT family. | 0.985 |
| DM82_4657 | glyA2 | DM82_4657 | DM82_4651 | Electron transfer flavodomain protein. | Serine hydroxymethyltransferase 2; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.938 |
| DM82_4657 | glyA2_1 | DM82_4657 | DM82_2426 | Electron transfer flavodomain protein. | Beta-eliminating lyase family protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.912 |
| DM82_4657 | kbl | DM82_4657 | DM82_3959 | Electron transfer flavodomain protein. | 2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.901 |
| DM82_4657 | ltaA | DM82_4657 | DM82_5239 | Electron transfer flavodomain protein. | L-allo-threonine aldolase. | 0.901 |
| DM82_4657 | ltaE | DM82_4657 | DM82_4241 | Electron transfer flavodomain protein. | Low specificity L-threonine aldolase. | 0.901 |
| DM82_4657 | soxB_2 | DM82_4657 | DM82_5562 | Electron transfer flavodomain protein. | soxB: sarcosine oxidase, beta subunit. | 0.950 |
| gcvP | DM82_4657 | DM82_3089 | DM82_4657 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Electron transfer flavodomain protein. | 0.922 |
| gcvP | gcvT_2 | DM82_3089 | DM82_5560 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | soxA: sarcosine oxidase, alpha subunit; Belongs to the GcvT family. | 0.999 |
| gcvP | glyA2 | DM82_3089 | DM82_4651 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Serine hydroxymethyltransferase 2; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.995 |
| gcvP | glyA2_1 | DM82_3089 | DM82_2426 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Beta-eliminating lyase family protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.995 |
| gcvP | kbl | DM82_3089 | DM82_3959 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.943 |
| gcvP | ltaA | DM82_3089 | DM82_5239 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | L-allo-threonine aldolase. | 0.959 |
| gcvP | ltaE | DM82_3089 | DM82_4241 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Low specificity L-threonine aldolase. | 0.959 |
| gcvP | soxB_2 | DM82_3089 | DM82_5562 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | soxB: sarcosine oxidase, beta subunit. | 0.909 |
| gcvP | ydfG_1 | DM82_3089 | DM82_2427 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Short chain dehydrogenase family protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.688 |
| gcvT_2 | DM82_4657 | DM82_5560 | DM82_4657 | soxA: sarcosine oxidase, alpha subunit; Belongs to the GcvT family. | Electron transfer flavodomain protein. | 0.985 |
| gcvT_2 | gcvP | DM82_5560 | DM82_3089 | soxA: sarcosine oxidase, alpha subunit; Belongs to the GcvT family. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.999 |
| gcvT_2 | glyA2 | DM82_5560 | DM82_4651 | soxA: sarcosine oxidase, alpha subunit; Belongs to the GcvT family. | Serine hydroxymethyltransferase 2; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.974 |
