Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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experimentally determined
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gene co-occurrence
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ilvC_2Acetohydroxy acid isomeroreductase, catalytic domain protein; Belongs to the ketol-acid reductoisomerase family. (353 aa)    
Predicted Functional Partners:
ilvN
Acolac_sm: acetolactate synthase, small subunit.
 
 
 0.997
ilvD
ilvD: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family.
 
 
 0.990
ilvB
Acolac_lg: acetolactate synthase, large subunit, biosynthetic type.
 
 
 0.990
ilvB_2
Thiamine pyrophosphate enzyme, central domain protein.
 
 
 0.988
ilvB_1
Thiamine pyrophosphate enzyme, central domain protein; Belongs to the TPP enzyme family.
 
 
 0.985
ilvG
Thiamine pyrophosphate enzyme, central domain protein; Belongs to the TPP enzyme family.
 
 
 0.983
budB
Thiamine pyrophosphate enzyme, central domain protein; Belongs to the TPP enzyme family.
 
 
 0.976
leuC
3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
  
 0.958
leuD
3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
 
  
 0.945
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
  
  
 
0.921
Your Current Organism:
Burkholderia oklahomensis
NCBI taxonomy Id: 342113
Other names: B. oklahomensis, Burkholderia oklahomensis Glass et al. 2006, CCUG 51349, DSM 21774, LMG 23618, LMG:23618, NCTC 13387, strain C6786
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