| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DM82_4468 | bfr | DM82_4468 | DM82_4470 | BFD-like [2Fe-2S] binding domain protein. | Bacterioferritin; Iron-storage protein. | 0.930 |
| DM82_4468 | murI | DM82_4468 | DM82_4469 | BFD-like [2Fe-2S] binding domain protein. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.562 |
| bfr | DM82_4468 | DM82_4470 | DM82_4468 | Bacterioferritin; Iron-storage protein. | BFD-like [2Fe-2S] binding domain protein. | 0.930 |
| bfr | fumB | DM82_4470 | DM82_4471 | Bacterioferritin; Iron-storage protein. | Hydrolyase, tartrate alpha subunit/fumarate, Fe-S type domain protein; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | 0.543 |
| bfr | murI | DM82_4470 | DM82_4469 | Bacterioferritin; Iron-storage protein. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.651 |
| fumB | bfr | DM82_4471 | DM82_4470 | Hydrolyase, tartrate alpha subunit/fumarate, Fe-S type domain protein; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Bacterioferritin; Iron-storage protein. | 0.543 |
| fumB | murI | DM82_4471 | DM82_4469 | Hydrolyase, tartrate alpha subunit/fumarate, Fe-S type domain protein; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.528 |
| fumB | rdgB | DM82_4471 | DM82_2208 | Hydrolyase, tartrate alpha subunit/fumarate, Fe-S type domain protein; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.415 |
| gdhA | glsA | DM82_2587 | DM82_4723 | glu/Leu/Phe/Val dehydrogenase, dimerization domain protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Gln_ase: glutaminase A; Belongs to the glutaminase family. | 0.921 |
| gdhA | murI | DM82_2587 | DM82_4469 | glu/Leu/Phe/Val dehydrogenase, dimerization domain protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.936 |
| glsA | gdhA | DM82_4723 | DM82_2587 | Gln_ase: glutaminase A; Belongs to the glutaminase family. | glu/Leu/Phe/Val dehydrogenase, dimerization domain protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.921 |
| glsA | murD | DM82_4723 | DM82_2695 | Gln_ase: glutaminase A; Belongs to the glutaminase family. | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.905 |
| glsA | murI | DM82_4723 | DM82_4469 | Gln_ase: glutaminase A; Belongs to the glutaminase family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.927 |
| murD | glsA | DM82_2695 | DM82_4723 | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | Gln_ase: glutaminase A; Belongs to the glutaminase family. | 0.905 |
| murD | murE | DM82_2695 | DM82_2698 | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | UDP-N-acetylmuramyl-tripeptide synthetase family protein; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | 0.996 |
| murD | murF | DM82_2695 | DM82_2697 | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase family protein; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. | 0.993 |
| murD | murG | DM82_2695 | DM82_2692 | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. | 0.993 |
| murD | murI | DM82_2695 | DM82_4469 | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.977 |
| murE | murD | DM82_2698 | DM82_2695 | UDP-N-acetylmuramyl-tripeptide synthetase family protein; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.996 |
| murE | murF | DM82_2698 | DM82_2697 | UDP-N-acetylmuramyl-tripeptide synthetase family protein; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase family protein; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. | 0.999 |