node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Patl_0021 | def | Patl_0021 | Patl_0023 | 16S rRNA m(5)C-967 methyltransferase; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. | 0.926 |
Patl_0021 | fmt | Patl_0021 | Patl_0022 | 16S rRNA m(5)C-967 methyltransferase; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.988 |
Patl_3057 | Patl_3735 | Patl_3057 | Patl_3735 | PFAM: formyl transferase-like; KEGG: sye:Syncc9902_1100 phosphoribosylglycinamide formyltransferase. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.919 |
Patl_3057 | fmt | Patl_3057 | Patl_0022 | PFAM: formyl transferase-like; KEGG: sye:Syncc9902_1100 phosphoribosylglycinamide formyltransferase. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.921 |
Patl_3057 | folD | Patl_3057 | Patl_3139 | PFAM: formyl transferase-like; KEGG: sye:Syncc9902_1100 phosphoribosylglycinamide formyltransferase. | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.955 |
Patl_3057 | gcvT | Patl_3057 | Patl_3592 | PFAM: formyl transferase-like; KEGG: sye:Syncc9902_1100 phosphoribosylglycinamide formyltransferase. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.921 |
Patl_3057 | glyA | Patl_3057 | Patl_1299 | PFAM: formyl transferase-like; KEGG: sye:Syncc9902_1100 phosphoribosylglycinamide formyltransferase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.959 |
Patl_3057 | purN | Patl_3057 | Patl_2490 | PFAM: formyl transferase-like; KEGG: sye:Syncc9902_1100 phosphoribosylglycinamide formyltransferase. | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.927 |
Patl_3735 | Patl_3057 | Patl_3735 | Patl_3057 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | PFAM: formyl transferase-like; KEGG: sye:Syncc9902_1100 phosphoribosylglycinamide formyltransferase. | 0.919 |
Patl_3735 | fmt | Patl_3735 | Patl_0022 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.935 |
Patl_3735 | gcvT | Patl_3735 | Patl_3592 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.927 |
Patl_3735 | glyA | Patl_3735 | Patl_1299 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.940 |
Patl_3735 | purN | Patl_3735 | Patl_2490 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.919 |
def | Patl_0021 | Patl_0023 | Patl_0021 | Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. | 16S rRNA m(5)C-967 methyltransferase; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.926 |
def | fmt | Patl_0023 | Patl_0022 | Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.984 |
def | nusB | Patl_0023 | Patl_1315 | Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. | NusB antitermination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. | 0.415 |
fmt | Patl_0021 | Patl_0022 | Patl_0021 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 16S rRNA m(5)C-967 methyltransferase; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.988 |
fmt | Patl_3057 | Patl_0022 | Patl_3057 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | PFAM: formyl transferase-like; KEGG: sye:Syncc9902_1100 phosphoribosylglycinamide formyltransferase. | 0.921 |
fmt | Patl_3735 | Patl_0022 | Patl_3735 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.935 |
fmt | def | Patl_0022 | Patl_0023 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. | 0.984 |