Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
fadI3-ketoacyl-CoA thiolase; Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. (436 aa)    
Predicted Functional Partners:
Patl_0201
3-hydroxyacyl-CoA dehydrogenase; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
 0.999
Patl_1664
3-hydroxyacyl-CoA dehydrogenase; Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3- hydroxyacyl-CoA dehydrogenase activities. Belongs to the enoyl-CoA hydratase/isomerase family. In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
 
 0.999
Patl_1916
PFAM: Enoyl-CoA hydratase/isomerase 3-hydroxyacyl-CoA dehydrogenase-like 3-hydroxyacyl-CoA dehydrogenase, NAD-binding; KEGG: ccr:CC3189 fatty oxidation complex, alpha subunit; Belongs to the enoyl-CoA hydratase/isomerase family.
 0.998
Patl_1688
PFAM: acyl-CoA dehydrogenase-like; KEGG: pha:PSHAb0374 acyl-coenzyme A dehydrogenase (ACDH).
 
 0.987
Patl_2492
PFAM: acyl-CoA dehydrogenase-like; KEGG: ilo:IL1665 oxidoreductase, acyl-CoA dehydrogenase family.
 
 0.987
Patl_2591
Phosphotransacetylase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family.
    
 0.955
acsA
Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
  
 
 0.954
Patl_2923
KEGG: pha:PSHAa1454 acetyl-CoA acetyltransferase with thiolase domain; TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal; Belongs to the thiolase-like superfamily. Thiolase family.
  
  
 
0.948
fadA
3-ketoacyl-CoA thiolase; Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
  
  
 
0.945
Patl_1420
KEGG: cps:CPS_2821 putative 2-methylcitrate synthase; TIGRFAM: 2-methylcitrate synthase/citrate synthase II; PFAM: Citrate synthase; Belongs to the citrate synthase family.
  
 0.944
Your Current Organism:
Pseudoalteromonas atlantica
NCBI taxonomy Id: 342610
Other names: P. atlantica T6c, Pseudoalteromonas atlantica T6c, Pseudoalteromonas atlantica str. T6c, Pseudoalteromonas atlantica strain T6c
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.