| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Patl_2002 | pyrD | Patl_2002 | Patl_2003 | PFAM: NAD-glutamate dehydrogenase; KEGG: pha:PSHAa1670 glutamate dehydrogenase. | Dihydroorotate oxidase A; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | 0.765 |
| Patl_2002 | rlmL | Patl_2002 | Patl_2005 | PFAM: NAD-glutamate dehydrogenase; KEGG: pha:PSHAa1670 glutamate dehydrogenase. | 23S rRNA m(2)G-2445 methyltransferase; Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Belongs to the methyltransferase superfamily. RlmKL family. | 0.439 |
| Patl_2002 | zapC | Patl_2002 | Patl_2004 | PFAM: NAD-glutamate dehydrogenase; KEGG: pha:PSHAa1670 glutamate dehydrogenase. | Protein of unknown function DUF1379; Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ. | 0.674 |
| Patl_2006 | pyrD | Patl_2006 | Patl_2003 | PFAM: SMC protein-like ABC transporter related; SMART: ATPase; KEGG: ppr:PBPRA1771 putative ABC transporter, ATP-binding protein. | Dihydroorotate oxidase A; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | 0.599 |
| Patl_2006 | rlmL | Patl_2006 | Patl_2005 | PFAM: SMC protein-like ABC transporter related; SMART: ATPase; KEGG: ppr:PBPRA1771 putative ABC transporter, ATP-binding protein. | 23S rRNA m(2)G-2445 methyltransferase; Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Belongs to the methyltransferase superfamily. RlmKL family. | 0.787 |
| Patl_2006 | zapC | Patl_2006 | Patl_2004 | PFAM: SMC protein-like ABC transporter related; SMART: ATPase; KEGG: ppr:PBPRA1771 putative ABC transporter, ATP-binding protein. | Protein of unknown function DUF1379; Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ. | 0.632 |
| Patl_3379 | proQ | Patl_3379 | Patl_1992 | PFAM: protein of unknown function DUF1414; KEGG: pmu:PM1884 hypothetical HI0840; Belongs to the UPF0352 family. | ProQ activator of osmoprotectant transporter ProP; RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities; Belongs to the ProQ family. | 0.731 |
| Patl_3379 | rraB | Patl_3379 | Patl_1031 | PFAM: protein of unknown function DUF1414; KEGG: pmu:PM1884 hypothetical HI0840; Belongs to the UPF0352 family. | Protein of unknown function DUF1260; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. | 0.765 |
| Patl_3379 | seqA | Patl_3379 | Patl_2199 | PFAM: protein of unknown function DUF1414; KEGG: pmu:PM1884 hypothetical HI0840; Belongs to the UPF0352 family. | Negative regulator of replication initiation; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. | 0.763 |
| Patl_3379 | yihI | Patl_3379 | Patl_0012 | PFAM: protein of unknown function DUF1414; KEGG: pmu:PM1884 hypothetical HI0840; Belongs to the UPF0352 family. | Protein of unknown function DUF414; A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis. Belongs to the YihI family. | 0.763 |
| Patl_3379 | zapC | Patl_3379 | Patl_2004 | PFAM: protein of unknown function DUF1414; KEGG: pmu:PM1884 hypothetical HI0840; Belongs to the UPF0352 family. | Protein of unknown function DUF1379; Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ. | 0.616 |
| ftsZ | zapC | Patl_3514 | Patl_2004 | Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. | Protein of unknown function DUF1379; Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ. | 0.925 |
| proQ | Patl_3379 | Patl_1992 | Patl_3379 | ProQ activator of osmoprotectant transporter ProP; RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities; Belongs to the ProQ family. | PFAM: protein of unknown function DUF1414; KEGG: pmu:PM1884 hypothetical HI0840; Belongs to the UPF0352 family. | 0.731 |
| proQ | rraB | Patl_1992 | Patl_1031 | ProQ activator of osmoprotectant transporter ProP; RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities; Belongs to the ProQ family. | Protein of unknown function DUF1260; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. | 0.773 |
| proQ | seqA | Patl_1992 | Patl_2199 | ProQ activator of osmoprotectant transporter ProP; RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities; Belongs to the ProQ family. | Negative regulator of replication initiation; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. | 0.756 |
| proQ | yihI | Patl_1992 | Patl_0012 | ProQ activator of osmoprotectant transporter ProP; RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities; Belongs to the ProQ family. | Protein of unknown function DUF414; A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis. Belongs to the YihI family. | 0.768 |
| proQ | zapC | Patl_1992 | Patl_2004 | ProQ activator of osmoprotectant transporter ProP; RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities; Belongs to the ProQ family. | Protein of unknown function DUF1379; Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ. | 0.669 |
| pyrD | Patl_2002 | Patl_2003 | Patl_2002 | Dihydroorotate oxidase A; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | PFAM: NAD-glutamate dehydrogenase; KEGG: pha:PSHAa1670 glutamate dehydrogenase. | 0.765 |
| pyrD | Patl_2006 | Patl_2003 | Patl_2006 | Dihydroorotate oxidase A; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | PFAM: SMC protein-like ABC transporter related; SMART: ATPase; KEGG: ppr:PBPRA1771 putative ABC transporter, ATP-binding protein. | 0.599 |
| pyrD | rlmL | Patl_2003 | Patl_2005 | Dihydroorotate oxidase A; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | 23S rRNA m(2)G-2445 methyltransferase; Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Belongs to the methyltransferase superfamily. RlmKL family. | 0.696 |