STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hisATIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: vfi:VF1017 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. (244 aa)    
Predicted Functional Partners:
hisB
KEGG: ilo:IL1837 imidazoleglycerol-phosphate dehydratase; TIGRFAM: histidinol-phosphatase histidinol-phosphate phosphatase family protein hydrolase, HAD-superfamily, subfamily IIIA; PFAM: imidazoleglycerol-phosphate dehydratase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.
 
  
 0.999
hisH
Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
 
 0.999
hisF
Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
 
0.999
hisI
PFAM: phosphoribosyl-AMP cyclohydrolase phosphoribosyl-ATP pyrophosphohydrolase; KEGG: yps:YPTB1555 histidine biosynthesis bifunctional protein; In the N-terminal section; belongs to the PRA-CH family.
 
 0.999
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
 
  
 0.997
hisC
TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II; KEGG: plu:plu1569 histidinol dehydrogenase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
 
  
 0.996
hisG
ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
 
  
 0.994
Patl_1130
PFAM: aminotransferase, class I and II; KEGG: cps:CPS_1142 CobC protein.
 
  
 0.852
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
  
  
 0.835
Patl_1278
KEGG: cps:CPS_1107 phosphoserine phosphatase; TIGRFAM: phosphoserine phosphatase SerB HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase-like hydrolase Haloacid dehalogenase-like hydrolase, type 3.
  
  
 0.774
Your Current Organism:
Pseudoalteromonas atlantica
NCBI taxonomy Id: 342610
Other names: P. atlantica T6c, Pseudoalteromonas atlantica T6c, Pseudoalteromonas atlantica str. T6c, Pseudoalteromonas atlantica strain T6c
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.