node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Patl_0139 | Patl_3565 | Patl_0139 | Patl_3565 | TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; PFAM: Haloacid dehalogenase-like hydrolase; KEGG: cps:CPS_0423 HAD-superfamily hydrolase, subfamily IA, variant 3 family protein. | PFAM: 5'-Nucleotidase-like; KEGG: mag:amb3606 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterase; Belongs to the 5'-nucleotidase family. | 0.902 |
Patl_0139 | surE | Patl_0139 | Patl_3860 | TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; PFAM: Haloacid dehalogenase-like hydrolase; KEGG: cps:CPS_0423 HAD-superfamily hydrolase, subfamily IA, variant 3 family protein. | 5'-nucleotidase / 3'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.912 |
Patl_0139 | tdk | Patl_0139 | Patl_0626 | TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; PFAM: Haloacid dehalogenase-like hydrolase; KEGG: cps:CPS_0423 HAD-superfamily hydrolase, subfamily IA, variant 3 family protein. | PFAM: thymidine kinase; KEGG: vvy:VV1363 thymidine kinase. | 0.902 |
Patl_0139 | thyA | Patl_0139 | Patl_3837 | TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; PFAM: Haloacid dehalogenase-like hydrolase; KEGG: cps:CPS_0423 HAD-superfamily hydrolase, subfamily IA, variant 3 family protein. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.903 |
Patl_0139 | tmk | Patl_0139 | Patl_2117 | TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; PFAM: Haloacid dehalogenase-like hydrolase; KEGG: cps:CPS_0423 HAD-superfamily hydrolase, subfamily IA, variant 3 family protein. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.901 |
Patl_3565 | Patl_0139 | Patl_3565 | Patl_0139 | PFAM: 5'-Nucleotidase-like; KEGG: mag:amb3606 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterase; Belongs to the 5'-nucleotidase family. | TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; PFAM: Haloacid dehalogenase-like hydrolase; KEGG: cps:CPS_0423 HAD-superfamily hydrolase, subfamily IA, variant 3 family protein. | 0.902 |
Patl_3565 | surE | Patl_3565 | Patl_3860 | PFAM: 5'-Nucleotidase-like; KEGG: mag:amb3606 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterase; Belongs to the 5'-nucleotidase family. | 5'-nucleotidase / 3'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.937 |
Patl_3565 | tdk | Patl_3565 | Patl_0626 | PFAM: 5'-Nucleotidase-like; KEGG: mag:amb3606 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterase; Belongs to the 5'-nucleotidase family. | PFAM: thymidine kinase; KEGG: vvy:VV1363 thymidine kinase. | 0.920 |
Patl_3565 | thyA | Patl_3565 | Patl_3837 | PFAM: 5'-Nucleotidase-like; KEGG: mag:amb3606 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterase; Belongs to the 5'-nucleotidase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.905 |
Patl_3565 | tmk | Patl_3565 | Patl_2117 | PFAM: 5'-Nucleotidase-like; KEGG: mag:amb3606 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterase; Belongs to the 5'-nucleotidase family. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.912 |
Patl_3735 | gcvT | Patl_3735 | Patl_3592 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.927 |
Patl_3735 | glyA | Patl_3735 | Patl_1299 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.940 |
Patl_3735 | tdk | Patl_3735 | Patl_0626 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | PFAM: thymidine kinase; KEGG: vvy:VV1363 thymidine kinase. | 0.455 |
Patl_3735 | thyA | Patl_3735 | Patl_3837 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.997 |
Patl_3735 | tmk | Patl_3735 | Patl_2117 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.416 |
Patl_3955 | folD | Patl_3955 | Patl_3139 | KEGG: hin:HI1444 510 methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.939 |
Patl_3955 | gcvT | Patl_3955 | Patl_3592 | KEGG: hin:HI1444 510 methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.940 |
Patl_3955 | glyA | Patl_3955 | Patl_1299 | KEGG: hin:HI1444 510 methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.951 |
Patl_3955 | thyA | Patl_3955 | Patl_3837 | KEGG: hin:HI1444 510 methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.931 |
folD | Patl_3955 | Patl_3139 | Patl_3955 | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | KEGG: hin:HI1444 510 methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.939 |