STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
VE01_04850SET domain-containing protein. (451 aa)    
Predicted Functional Partners:
VE01_01610
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
    
 0.835
SET1
Histone-lysine N-methyltransferase, H3 lysine-4 specific; Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.
    
 0.773
VE01_07466
WD_REPEATS_REGION domain-containing protein.
    
 0.762
VE01_08899
B30.2/SPRY domain-containing protein.
    
 0.756
SWD1
Chromatin binding protein.
    
 0.756
VE01_05870
Uncharacterized protein.
    
 0.746
VE01_07495
SET domain-containing protein.
    
 0.722
HAT2
Histone acetyltransferase type B subunit 2.
    
 0.712
DOT1
Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones.
    
 0.702
HTB1
Histone H2B; Belongs to the histone H2B family.
    
 0.689
Your Current Organism:
Pseudogymnoascus verrucosus
NCBI taxonomy Id: 342668
Other names: P. verrucosus, UAMH 10579
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.