node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SG0280 | SG0404 | SG0280 | SG0404 | Cystathionine beta-lyase. | Aspartokinase I ThrA; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.953 |
SG0280 | cysK | SG0280 | SG1700 | Cystathionine beta-lyase. | Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.969 |
SG0280 | gshA | SG0280 | SG0541 | Cystathionine beta-lyase. | Gamma-glutamylcysteine synthase; Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily. | 0.819 |
SG0280 | ilvA | SG0280 | SG2393 | Cystathionine beta-lyase. | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.839 |
SG0280 | luxS | SG0280 | SG0542 | Cystathionine beta-lyase. | Autoinducer-2 production protein; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | 0.941 |
SG0280 | metB | SG0280 | SG2163 | Cystathionine beta-lyase. | Cystathionine gamma-synthase. | 0.964 |
SG0280 | metE | SG0280 | SG0092 | Cystathionine beta-lyase. | Tetrahydropteroyltriglutamate methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.981 |
SG0280 | patB | SG0280 | SG1250 | Cystathionine beta-lyase. | Putative aminotransferase. | 0.930 |
SG0280 | thrB | SG0280 | SG0405 | Cystathionine beta-lyase. | Homoserine kinase ThrB; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.838 |
SG0404 | SG0280 | SG0404 | SG0280 | Aspartokinase I ThrA; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Cystathionine beta-lyase. | 0.953 |
SG0404 | ilvA | SG0404 | SG2393 | Aspartokinase I ThrA; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.815 |
SG0404 | luxS | SG0404 | SG0542 | Aspartokinase I ThrA; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Autoinducer-2 production protein; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | 0.860 |
SG0404 | metB | SG0404 | SG2163 | Aspartokinase I ThrA; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Cystathionine gamma-synthase. | 0.953 |
SG0404 | metE | SG0404 | SG0092 | Aspartokinase I ThrA; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Tetrahydropteroyltriglutamate methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.945 |
SG0404 | mtnN | SG0404 | SG0503 | Aspartokinase I ThrA; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulatio [...] | 0.413 |
SG0404 | patB | SG0404 | SG1250 | Aspartokinase I ThrA; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Putative aminotransferase. | 0.827 |
SG0404 | thrB | SG0404 | SG0405 | Aspartokinase I ThrA; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Homoserine kinase ThrB; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.999 |
cysK | SG0280 | SG1700 | SG0280 | Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Cystathionine beta-lyase. | 0.969 |
cysK | gshA | SG1700 | SG0541 | Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Gamma-glutamylcysteine synthase; Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily. | 0.811 |
cysK | luxS | SG1700 | SG0542 | Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Autoinducer-2 production protein; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | 0.833 |