STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
leuCUnannotated protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (461 aa)    
Predicted Functional Partners:
leuA
Unannotated protein; Belongs to the alpha-IPM synthase/homocitrate synthase family.
 
 0.999
leuD1
Unannotated protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
 0.999
leuB
Unannotated protein; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
 0.999
ilvD
Unannotated protein; Belongs to the IlvD/Edd family.
 
 
 0.953
ilvC
Unannotated protein; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
  
 0.907
poxB
Unannotated protein; Belongs to the TPP enzyme family.
  
 
 0.889
yngG
Unannotated protein.
  
 
 0.845
ilvH
Unannotated protein.
 
  
 0.835
pyk
Unannotated protein; Belongs to the pyruvate kinase family.
    
 0.823
ldhA
Unannotated protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
    
 0.822
Your Current Organism:
Empedobacter falsenii
NCBI taxonomy Id: 343874
Other names: CCUG 51536, CIP 108861, E. falsenii, Empedobacter falsenii (Kampfer et al. 2006) Zhang et al. 2014, Wautersiella falsenii, Wautersiella falsenii (Kampfer et al. 2006) emend. Zhang et al. 2014, strain NF 993
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.