node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EDL60969.1 | EDL61182.1 | PM8797T_09624 | PM8797T_03104 | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | Nonspecific acid phosphatase precursor; COG0039 Malate/lactate dehydrogenases. | 0.827 |
EDL60969.1 | argJ | PM8797T_09624 | PM8797T_17387 | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | Bifunctional ornithine acetyltransferase/N-acetylglutamate synthase protein; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. | 0.519 |
EDL60969.1 | hisA | PM8797T_09624 | PM8797T_18679 | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. | 0.999 |
EDL60969.1 | hisB | PM8797T_09624 | PM8797T_05825 | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | COG0131 Imidazoleglycerol-phosphate dehydratase. | 0.976 |
EDL60969.1 | hisC | PM8797T_09624 | PM8797T_05830 | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.951 |
EDL60969.1 | hisD | PM8797T_09624 | PM8797T_00739 | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.976 |
EDL60969.1 | hisF | PM8797T_09624 | PM8797T_08019 | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.992 |
EDL60969.1 | hisG-2 | PM8797T_09624 | PM8797T_20034 | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.961 |
EDL60969.1 | hisH | PM8797T_09624 | PM8797T_18684 | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.976 |
EDL61182.1 | EDL60969.1 | PM8797T_03104 | PM8797T_09624 | Nonspecific acid phosphatase precursor; COG0039 Malate/lactate dehydrogenases. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | 0.827 |
EDL61182.1 | PheA | PM8797T_03104 | PM8797T_01609 | Nonspecific acid phosphatase precursor; COG0039 Malate/lactate dehydrogenases. | P-protein (PheA); COG1605 Chorismate mutase. | 0.473 |
EDL61182.1 | hisA | PM8797T_03104 | PM8797T_18679 | Nonspecific acid phosphatase precursor; COG0039 Malate/lactate dehydrogenases. | COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. | 0.822 |
EDL61182.1 | hisB | PM8797T_03104 | PM8797T_05825 | Nonspecific acid phosphatase precursor; COG0039 Malate/lactate dehydrogenases. | COG0131 Imidazoleglycerol-phosphate dehydratase. | 0.824 |
EDL61182.1 | hisC | PM8797T_03104 | PM8797T_05830 | Nonspecific acid phosphatase precursor; COG0039 Malate/lactate dehydrogenases. | COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.740 |
EDL61182.1 | hisD | PM8797T_03104 | PM8797T_00739 | Nonspecific acid phosphatase precursor; COG0039 Malate/lactate dehydrogenases. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.722 |
EDL61182.1 | hisF | PM8797T_03104 | PM8797T_08019 | Nonspecific acid phosphatase precursor; COG0039 Malate/lactate dehydrogenases. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.841 |
EDL61182.1 | hisG-2 | PM8797T_03104 | PM8797T_20034 | Nonspecific acid phosphatase precursor; COG0039 Malate/lactate dehydrogenases. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.522 |
EDL61182.1 | hisH | PM8797T_03104 | PM8797T_18684 | Nonspecific acid phosphatase precursor; COG0039 Malate/lactate dehydrogenases. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.815 |
PheA | EDL61182.1 | PM8797T_01609 | PM8797T_03104 | P-protein (PheA); COG1605 Chorismate mutase. | Nonspecific acid phosphatase precursor; COG0039 Malate/lactate dehydrogenases. | 0.473 |
PheA | hisA | PM8797T_01609 | PM8797T_18679 | P-protein (PheA); COG1605 Chorismate mutase. | COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. | 0.471 |