STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (909 aa)    
Predicted Functional Partners:
RecQ
COG0514 Superfamily II DNA helicase.
 
 0.979
EDL55998.1
DNA helicase; COG0514 Superfamily II DNA helicase.
  
 0.979
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
 
 0.884
recA
Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
 
 0.880
Ssb
COG0629 Single-stranded DNA-binding protein.
  
 
 0.846
leuS
COG0495 Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.
 
 
 
 0.823
EDL60575.1
DNA processing chain A; COG0758 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake.
   
 0.822
GltB_1
Glutamate synthase [NADPH] large chain; COG0067 Glutamate synthase domain 1.
  
  
 0.811
DinG
ATP-dependent helicase, DinG family protein; COG1199 Rad3-related DNA helicases.
   
 0.800
EDL60079.1
Hypothetical protein; COG0419 ATPase involved in DNA repair.
  
 0.717
Your Current Organism:
Gimesia maris
NCBI taxonomy Id: 344747
Other names: G. maris DSM 8797, Gimesia maris DSM 8797, Planctomyces maris DSM 8797, Planctomyces maris str. DSM 8797, Planctomyces maris strain DSM 8797
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.