STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DnaK_5DnaK protein (heat shock protein), HSP70/DnaK family; COG0443 Molecular chaperone; Belongs to the heat shock protein 70 family. (557 aa)    
Predicted Functional Partners:
dnaJ
Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]
 0.970
CbpA
Heat shock protein DnaJ-like protein; COG2214 DnaJ-class molecular chaperone.
 0.970
GrpE
COG0576 Molecular chaperone GrpE (heat shock protein).
  
 
 0.959
grpE
GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
 
 
 0.952
HtpG_2
COG0326 Molecular chaperone, HSP90 family.
   
 0.875
htpG
Heat shock protein 90; Molecular chaperone. Has ATPase activity.
   
 0.875
clpB
ATP-dependent chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.
  
 
 0.818
EDL60593.1
Negative regulator of genetic competence ClpC/MecB; COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family.
  
 
 0.818
DnaK_4
DnaK protein (heat shock protein), C-terminal region has VWA type A domain; COG0443 Molecular chaperone; Belongs to the heat shock protein 70 family.
 
    
0.797
RpoA_2
Probable DNA-directed RNA polymerase alpha chain; COG0457 FOG: TPR repeat.
  
 0.756
Your Current Organism:
Gimesia maris
NCBI taxonomy Id: 344747
Other names: G. maris DSM 8797, Gimesia maris DSM 8797, Planctomyces maris DSM 8797, Planctomyces maris str. DSM 8797, Planctomyces maris strain DSM 8797
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