C5167_019235 protein (Papaver somniferum) - STRING interaction network

Nodes:

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Score

C5167_019235

MFS domain-containing protein. (530 aa)

Predicted Functional Partners:

C5167_038860

0.439

C5167_011222

0.439

C5167_013281

0.430

C5167_046244

0.430

C5167_005283

0.415

C5167_023545

0.415

Your Current Organism:

Papaver somniferum

NCBI taxonomy Id: 3469
Other names: P. somniferum, Papaver somniferum L., Papaver somniferum convar. nigrum (Hayne) Alef., opium poppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C5167_005283	C5167_011222	A0A4Y7JAY8	A0A4Y7K3N9	Uncharacterized protein.	Lactamase_B domain-containing protein.	0.987
C5167_005283	C5167_019235	A0A4Y7JAY8	A0A4Y7ITJ3	Uncharacterized protein.	MFS domain-containing protein.	0.415
C5167_005283	C5167_038860	A0A4Y7JAY8	A0A4Y7IER3	Uncharacterized protein.	Beta-Casp domain-containing protein.	0.987
C5167_011222	C5167_005283	A0A4Y7K3N9	A0A4Y7JAY8	Lactamase_B domain-containing protein.	Uncharacterized protein.	0.987
C5167_011222	C5167_019235	A0A4Y7K3N9	A0A4Y7ITJ3	Lactamase_B domain-containing protein.	MFS domain-containing protein.	0.439
C5167_011222	C5167_023545	A0A4Y7K3N9	A0A4Y7JKX9	Lactamase_B domain-containing protein.	Uncharacterized protein.	0.987
C5167_013281	C5167_019235	A0A4Y7J3A4	A0A4Y7ITJ3	Uncharacterized protein.	MFS domain-containing protein.	0.430
C5167_019235	C5167_005283	A0A4Y7ITJ3	A0A4Y7JAY8	MFS domain-containing protein.	Uncharacterized protein.	0.415
C5167_019235	C5167_011222	A0A4Y7ITJ3	A0A4Y7K3N9	MFS domain-containing protein.	Lactamase_B domain-containing protein.	0.439
C5167_019235	C5167_013281	A0A4Y7ITJ3	A0A4Y7J3A4	MFS domain-containing protein.	Uncharacterized protein.	0.430
C5167_019235	C5167_023545	A0A4Y7ITJ3	A0A4Y7JKX9	MFS domain-containing protein.	Uncharacterized protein.	0.415
C5167_019235	C5167_038860	A0A4Y7ITJ3	A0A4Y7IER3	MFS domain-containing protein.	Beta-Casp domain-containing protein.	0.439
C5167_019235	C5167_046244	A0A4Y7ITJ3	A0A4Y7LFZ8	MFS domain-containing protein.	Uncharacterized protein.	0.430
C5167_023545	C5167_011222	A0A4Y7JKX9	A0A4Y7K3N9	Uncharacterized protein.	Lactamase_B domain-containing protein.	0.987
C5167_023545	C5167_019235	A0A4Y7JKX9	A0A4Y7ITJ3	Uncharacterized protein.	MFS domain-containing protein.	0.415
C5167_023545	C5167_038860	A0A4Y7JKX9	A0A4Y7IER3	Uncharacterized protein.	Beta-Casp domain-containing protein.	0.987
C5167_038860	C5167_005283	A0A4Y7IER3	A0A4Y7JAY8	Beta-Casp domain-containing protein.	Uncharacterized protein.	0.987
C5167_038860	C5167_019235	A0A4Y7IER3	A0A4Y7ITJ3	Beta-Casp domain-containing protein.	MFS domain-containing protein.	0.439
C5167_038860	C5167_023545	A0A4Y7IER3	A0A4Y7JKX9	Beta-Casp domain-containing protein.	Uncharacterized protein.	0.987
C5167_046244	C5167_019235	A0A4Y7LFZ8	A0A4Y7ITJ3	Uncharacterized protein.	MFS domain-containing protein.	0.430

Network Stats

number of nodes:

4

number of edges:

4

average node degree:

2

avg. local clustering coefficient:

0.833

expected number of edges:

3

PPI enrichment p-value:

0.335

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042273

Ribosomal large subunit biogenesis

5 of 88

2.02

2.89

6.58e-07

GO:0006364

rRNA processing

7 of 315

1.61

2.51

9.85e-08

GO:0042254

Ribosome biogenesis

8 of 423

1.54

2.48

2.40e-08

GO:0000463

Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

3 of 21

2.42

2.18

8.03e-05

GO:0051302

Regulation of cell division

3 of 51

2.04

1.6

0.00073

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003723

RNA binding

7 of 1612

0.91

0.62

0.0094

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005730

Nucleolus

9 of 364

1.66

3.44

9.07e-12

GO:0030687

Preribosome, large subunit precursor

4 of 29

2.41

3.4

2.52e-07

GO:0070545

PeBoW complex

2 of 2

3.27

2.15

0.00013

GO:1990904

Ribonucleoprotein complex

5 of 646

1.16

1.0

0.00095

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9781

Ribosomal large subunit biogenesis, and RNA helicase, DEAD-box type, Q motif

10 of 66

2.45

9.03

1.10e-20

CL:9540

rRNA processing, and Protein of unknown function DUF1068

11 of 199

2.01

6.62

7.60e-20

CL:9788

Preribosome, large subunit precursor, and Ribosomal large subunit biogenesis

6 of 43

2.41

5.14

3.81e-11

CL:9891

CEBPZ/Mak21-like, and RNA helicase, DEAD-box type, Q motif

4 of 5

3.17

4.71

2.56e-09

CL:9789

Preribosome, large subunit precursor, and Protein of unknown function DUF1350

4 of 26

2.45

3.3

4.43e-07

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8868773

rRNA processing in the nucleus and cytosol

4 of 232

1.5

1.07

0.0041

MAP-6791226

Major pathway of rRNA processing in the nucleolus and cytosol

4 of 227

1.51

1.07

0.0041

MAP-72312

rRNA processing

4 of 238

1.49

1.06

0.0041

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005730

Nucleolus

7 of 188

1.84

3.4

2.57e-09

GOCC:0070545

PeBoW complex

2 of 2

3.27

2.01

0.00024

GOCC:0031981

Nuclear lumen

8 of 792

1.27

1.67

4.94e-07

GOCC:0043232

Intracellular non-membrane-bounded organelle

8 of 1480

1.0

1.03

2.18e-05

GOCC:0043226

Organelle

11 of 9707

0.32

0.25

0.0321

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0698

rRNA processing

2 of 16

2.36

1.08

0.0103

KW-0690

Ribosome biogenesis

2 of 15

2.39

1.08

0.0103

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR040155

CEBPZ/Mak21-like

2 of 2

3.27

1.15

0.0085

IPR007109

Brix domain

2 of 5

2.87

1.01

0.0148

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00879

The Brix domain is found in a number of eukaryotic proteins including SSF proteins from yeast and humans, Arabidopsis thaliana Peter Pan-like protein and several hypothetical proteins.

2 of 5

2.87

1.43

0.0026

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