C5167_024828 protein (Papaver somniferum) - STRING interaction network

Nodes:

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

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[Homology]

Score

C5167_024828

Uncharacterized protein. (278 aa)

Predicted Functional Partners:

C5167_008306

0.776

C5167_024264

0.675

C5167_032062

0.675

C5167_017009

0.596

C5167_004709

0.548

C5167_010081

0.548

C5167_005562

0.546

C5167_022989

0.546

C5167_020668

0.538

C5167_043996

0.538

Your Current Organism:

Papaver somniferum

NCBI taxonomy Id: 3469
Other names: P. somniferum, Papaver somniferum L., Papaver somniferum convar. nigrum (Hayne) Alef., opium poppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C5167_004709	C5167_005562	A0A4Y7IA12	A0A4Y7JCK2	Uncharacterized protein.	Uncharacterized protein.	0.423
C5167_004709	C5167_010081	A0A4Y7IA12	A0A4Y7K3A9	Uncharacterized protein.	Uncharacterized protein.	0.900
C5167_004709	C5167_022989	A0A4Y7IA12	A0A4Y7JMI4	Uncharacterized protein.	Uncharacterized protein.	0.423
C5167_004709	C5167_024828	A0A4Y7IA12	A0A4Y7JQT0	Uncharacterized protein.	Uncharacterized protein.	0.548
C5167_005562	C5167_004709	A0A4Y7JCK2	A0A4Y7IA12	Uncharacterized protein.	Uncharacterized protein.	0.423
C5167_005562	C5167_010081	A0A4Y7JCK2	A0A4Y7K3A9	Uncharacterized protein.	Uncharacterized protein.	0.423
C5167_005562	C5167_024828	A0A4Y7JCK2	A0A4Y7JQT0	Uncharacterized protein.	Uncharacterized protein.	0.546
C5167_008306	C5167_017009	A0A4Y7JV79	A0A4Y7II72	Inos-1-P_synth domain-containing protein.	Uncharacterized protein.	0.409
C5167_008306	C5167_024828	A0A4Y7JV79	A0A4Y7JQT0	Inos-1-P_synth domain-containing protein.	Uncharacterized protein.	0.776
C5167_010081	C5167_004709	A0A4Y7K3A9	A0A4Y7IA12	Uncharacterized protein.	Uncharacterized protein.	0.900
C5167_010081	C5167_005562	A0A4Y7K3A9	A0A4Y7JCK2	Uncharacterized protein.	Uncharacterized protein.	0.423
C5167_010081	C5167_022989	A0A4Y7K3A9	A0A4Y7JMI4	Uncharacterized protein.	Uncharacterized protein.	0.423
C5167_010081	C5167_024828	A0A4Y7K3A9	A0A4Y7JQT0	Uncharacterized protein.	Uncharacterized protein.	0.548
C5167_017009	C5167_008306	A0A4Y7II72	A0A4Y7JV79	Uncharacterized protein.	Inos-1-P_synth domain-containing protein.	0.409
C5167_017009	C5167_024828	A0A4Y7II72	A0A4Y7JQT0	Uncharacterized protein.	Uncharacterized protein.	0.596
C5167_020668	C5167_024264	A0A4Y7IWZ9	A0A4Y7JPK2	Imidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. In the C-terminal section; belongs to the HisA/HisF family.	Aminotran_1_2 domain-containing protein.	0.989
C5167_020668	C5167_024828	A0A4Y7IWZ9	A0A4Y7JQT0	Imidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. In the C-terminal section; belongs to the HisA/HisF family.	Uncharacterized protein.	0.538
C5167_020668	C5167_032062	A0A4Y7IWZ9	A0A4Y7KAE1	Imidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. In the C-terminal section; belongs to the HisA/HisF family.	Aminotran_1_2 domain-containing protein.	0.989
C5167_022989	C5167_004709	A0A4Y7JMI4	A0A4Y7IA12	Uncharacterized protein.	Uncharacterized protein.	0.423
C5167_022989	C5167_010081	A0A4Y7JMI4	A0A4Y7K3A9	Uncharacterized protein.	Uncharacterized protein.	0.423

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

35

average node degree:

6.36

avg. local clustering coefficient:

0.832

expected number of edges:

11

PPI enrichment p-value:

2.69e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051231

Spindle elongation

9 of 18

3.68

15.08

2.98e-28

GO:0090307

Mitotic spindle assembly

9 of 29

3.47

14.26

5.19e-27

GO:0007018

Microtubule-based movement

11 of 206

2.71

12.55

5.19e-27

GO:0000070

Mitotic sister chromatid segregation

9 of 120

2.86

11.01

2.02e-22

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008574

Plus-end-directed microtubule motor activity

9 of 44

3.29

13.54

5.17e-26

GO:0003777

Microtubule motor activity

11 of 183

2.76

12.96

1.74e-27

GO:0008017

Microtubule binding

11 of 499

2.32

9.35

2.16e-23

GO:0005524

ATP binding

11 of 10499

1.0

1.25

3.04e-09

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0072686

Mitotic spindle

9 of 48

3.25

13.33

1.06e-25

GO:0005876

Spindle microtubule

9 of 80

3.03

12.2

3.73e-24

GO:0005874

Microtubule

11 of 607

2.24

8.69

8.18e-23

GO:0005737

Cytoplasm

10 of 38115

0.4

0.3

0.0168

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:145257

Kinesin motor domain, conserved site, and Plus-end directed microtubule sliding

8 of 59

3.11

10.29

4.49e-20

CL:145259

Mixed, incl. Spindle elongation, and Microtubule depolymerization

7 of 45

3.17

9.5

2.02e-18

CL:145261

Mixed, incl. Spindle elongation, and Kinesin-like protein KIF15/KIN-12

6 of 37

3.19

8.03

1.45e-15

CL:145263

Mixed, incl. Spindle elongation, and Regulation of spindle assembly

4 of 20

3.28

5.06

6.25e-10

CL:145264

Mixed, incl. Spindle elongation, and Regulation of spindle assembly

3 of 12

3.38

3.6

3.15e-07

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04144

Endocytosis

10 of 1052

1.96

5.82

1.83e-17

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-983189

Kinesins

10 of 164

2.77

11.77

1.15e-24

MAP-6811434

COPI-dependent Golgi-to-ER retrograde traffic

10 of 363

2.42

9.24

1.35e-21

MAP-8856688

Golgi-to-ER retrograde transport

10 of 467

2.31

8.44

1.08e-20

MAP-983231

Factors involved in megakaryocyte development and platelet production

10 of 531

2.25

8.04

2.89e-20

MAP-6811442

Intra-Golgi and retrograde Golgi-to-ER traffic

10 of 567

2.23

7.85

4.43e-20

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005876

Spindle microtubule

9 of 33

3.42

14.06

9.48e-27

GOCC:0015630

Microtubule cytoskeleton

10 of 944

2.01

6.12

9.42e-18

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0505

Motor protein

11 of 214

2.69

12.73

1.21e-27

KW-0067

ATP-binding

11 of 5170

1.31

2.29

7.38e-13

KW-0175

Coiled coil

10 of 10941

0.94

1.07

1.34e-07

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR047149

Kinesin-like protein KIF11-like

9 of 15

3.76

15.27

1.58e-28

IPR001752

Kinesin motor domain

11 of 160

2.82

13.34

7.21e-28

IPR036961

Kinesin motor domain superfamily

11 of 192

2.74

12.75

3.34e-27

IPR047241

Kinesin-like protein KIF11-like, kinesin motor domain

7 of 10

3.83

11.8

4.32e-22

IPR019821

Kinesin motor domain, conserved site

9 of 99

2.94

11.3

1.18e-22

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00129

Kinesin motor, catalytic domain. ATPase.

11 of 160

2.82

13.71

1.01e-28

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