C5167_008111 protein (Papaver somniferum) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

C5167_008111

ADH_zinc_N domain-containing protein. (181 aa)

Predicted Functional Partners:

C5167_001794

0.855

C5167_045722

0.855

C5167_013274

0.592

C5167_023320

0.528

C5167_004526

0.430

C5167_004527

0.430

C5167_037666

0.418

C5167_012548

0.418

C5167_010208

0.418

C5167_003681

0.418

Your Current Organism:

Papaver somniferum

NCBI taxonomy Id: 3469
Other names: P. somniferum, Papaver somniferum L., Papaver somniferum convar. nigrum (Hayne) Alef., opium poppy

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C5167_001794	C5167_008111	A0A4Y7L086	A0A4Y7JWR7	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.	ADH_zinc_N domain-containing protein.	0.855
C5167_001794	C5167_023320	A0A4Y7L086	A0A4Y7JNJ6	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.	ADH_N domain-containing protein.	0.883
C5167_003681	C5167_008111	A0A4Y7L2N9	A0A4Y7JWR7	Uncharacterized protein.	ADH_zinc_N domain-containing protein.	0.418
C5167_004526	C5167_008111	A0A4Y7JAY0	A0A4Y7JWR7	Uncharacterized protein.	ADH_zinc_N domain-containing protein.	0.430
C5167_004526	C5167_023320	A0A4Y7JAY0	A0A4Y7JNJ6	Uncharacterized protein.	ADH_N domain-containing protein.	0.430
C5167_004527	C5167_008111	A0A4Y7JBA6	A0A4Y7JWR7	Uncharacterized protein.	ADH_zinc_N domain-containing protein.	0.430
C5167_004527	C5167_023320	A0A4Y7JBA6	A0A4Y7JNJ6	Uncharacterized protein.	ADH_N domain-containing protein.	0.430
C5167_008111	C5167_001794	A0A4Y7JWR7	A0A4Y7L086	ADH_zinc_N domain-containing protein.	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.	0.855
C5167_008111	C5167_003681	A0A4Y7JWR7	A0A4Y7L2N9	ADH_zinc_N domain-containing protein.	Uncharacterized protein.	0.418
C5167_008111	C5167_004526	A0A4Y7JWR7	A0A4Y7JAY0	ADH_zinc_N domain-containing protein.	Uncharacterized protein.	0.430
C5167_008111	C5167_004527	A0A4Y7JWR7	A0A4Y7JBA6	ADH_zinc_N domain-containing protein.	Uncharacterized protein.	0.430
C5167_008111	C5167_010208	A0A4Y7JWR7	A0A4Y7K2F8	ADH_zinc_N domain-containing protein.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.418
C5167_008111	C5167_012548	A0A4Y7JWR7	A0A4Y7IYK3	ADH_zinc_N domain-containing protein.	Uncharacterized protein.	0.418
C5167_008111	C5167_013274	A0A4Y7JWR7	A0A4Y7J1U1	ADH_zinc_N domain-containing protein.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.592
C5167_008111	C5167_023320	A0A4Y7JWR7	A0A4Y7JNJ6	ADH_zinc_N domain-containing protein.	ADH_N domain-containing protein.	0.528
C5167_008111	C5167_037666	A0A4Y7JWR7	A0A4Y7I9J6	ADH_zinc_N domain-containing protein.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.418
C5167_008111	C5167_045722	A0A4Y7JWR7	A0A4Y7LD73	ADH_zinc_N domain-containing protein.	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.	0.855
C5167_010208	C5167_008111	A0A4Y7K2F8	A0A4Y7JWR7	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	ADH_zinc_N domain-containing protein.	0.418
C5167_012548	C5167_008111	A0A4Y7IYK3	A0A4Y7JWR7	Uncharacterized protein.	ADH_zinc_N domain-containing protein.	0.418
C5167_013274	C5167_008111	A0A4Y7J1U1	A0A4Y7JWR7	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	ADH_zinc_N domain-containing protein.	0.592

page 1 of 2

Network Stats

number of nodes:

7

number of edges:

21

average node degree:

6

avg. local clustering coefficient:

1

expected number of edges:

7

PPI enrichment p-value:

6.46e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016079

Synaptic vesicle exocytosis

3 of 14

2.89

2.81

3.61e-05

GO:0006887

Exocytosis

4 of 92

2.2

2.58

3.61e-05

GO:0048791

Calcium ion-regulated exocytosis of neurotransmitter

2 of 3

3.39

2.33

0.00024

GO:0016192

Vesicle-mediated transport

5 of 664

1.44

1.6

0.00011

GO:0140029

Exocytic process

2 of 30

2.39

1.33

0.0074

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019905

Syntaxin binding

3 of 37

2.47

2.2

0.00027

GO:0005484

SNAP receptor activity

2 of 40

2.26

0.88

0.0403

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0098793

Presynapse

5 of 109

2.22

4.07

3.57e-08

GO:0008021

Synaptic vesicle

3 of 46

2.38

2.54

6.10e-05

GO:0070161

Anchoring junction

4 of 281

1.72

1.95

0.00011

GO:0030672

Synaptic vesicle membrane

2 of 21

2.54

1.71

0.0019

GO:0031201

SNARE complex

2 of 43

2.23

1.36

0.0061

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:26734

Norepinephrine Neurotransmitter Release Cycle, and Rim-like

3 of 10

3.04

3.08

1.42e-05

CL:26699

Mixed, incl. Organic anion transporters, and Regulated exocytosis

4 of 94

2.19

2.78

1.42e-05

CL:6761

SNARE complex disassembly, and Other interleukin signaling

2 of 6

3.08

2.15

0.00044

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04130

SNARE interactions in vesicular transport

2 of 56

2.11

1.09

0.0167

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-449836

Other interleukin signaling

2 of 8

2.96

1.61

0.0031

MAP-181429

Serotonin Neurotransmitter Release Cycle

2 of 7

3.02

1.61

0.0031

MAP-212676

Dopamine Neurotransmitter Release Cycle

2 of 11

2.82

1.6

0.0031

MAP-210500

Glutamate Neurotransmitter Release Cycle

2 of 11

2.82

1.6

0.0031

MAP-181430

Norepinephrine Neurotransmitter Release Cycle

2 of 9

2.91

1.6

0.0031

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0098793

Presynapse

5 of 68

2.43

4.8

4.28e-09

GOCC:0045202

Synapse

6 of 249

1.94

3.88

4.28e-09

GOCC:0030672

Synaptic vesicle membrane

3 of 19

2.76

3.26

5.98e-06

GOCC:0048788

Cytoskeleton of presynaptic active zone

2 of 5

3.16

2.42

0.00017

GOCC:0031410

Cytoplasmic vesicle

4 of 672

1.34

1.21

0.0012

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR039032

Rim-like

2 of 3

3.39

1.61

0.0032

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (20%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About