node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MAG0435 | MAG0590 | MAG0435 | MAG0590 | Hypothetical protein; Belongs to the SecE/SEC61-gamma family. | Conserved hypothetical protein. | 0.900 |
MAG0435 | ffh | MAG0435 | MAG5820 | Hypothetical protein; Belongs to the SecE/SEC61-gamma family. | Signal Recognition Particle Protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. | 0.900 |
MAG0435 | ftsY | MAG0435 | MAG2040 | Hypothetical protein; Belongs to the SecE/SEC61-gamma family. | Cell division protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). | 0.900 |
MAG0435 | secA | MAG0435 | MAG2730 | Hypothetical protein; Belongs to the SecE/SEC61-gamma family. | Preprotein translocase SecA subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. | 0.900 |
MAG0435 | secD | MAG0435 | MAG2250 | Hypothetical protein; Belongs to the SecE/SEC61-gamma family. | Protein export membrane protein. | 0.900 |
MAG0435 | secY | MAG0435 | MAG5260 | Hypothetical protein; Belongs to the SecE/SEC61-gamma family. | Preprotein translocase SecY subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | 0.901 |
MAG0590 | MAG0435 | MAG0590 | MAG0435 | Conserved hypothetical protein. | Hypothetical protein; Belongs to the SecE/SEC61-gamma family. | 0.900 |
MAG0590 | atpE | MAG0590 | MAG3510 | Conserved hypothetical protein. | ATP synthase C chain; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. | 0.960 |
MAG0590 | ffh | MAG0590 | MAG5820 | Conserved hypothetical protein. | Signal Recognition Particle Protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. | 0.956 |
MAG0590 | ftsY | MAG0590 | MAG2040 | Conserved hypothetical protein. | Cell division protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). | 0.951 |
MAG0590 | rnpA | MAG0590 | MAG0580 | Conserved hypothetical protein. | Ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. | 0.972 |
MAG0590 | rpmH | MAG0590 | MAG7500 | Conserved hypothetical protein. | 50S ribosomal protein L34; Belongs to the bacterial ribosomal protein bL34 family. | 0.862 |
MAG0590 | rpsE | MAG0590 | MAG5300 | Conserved hypothetical protein. | 30S ribosomal protein S5; With S4 and S12 plays an important role in translational accuracy; Belongs to the universal ribosomal protein uS5 family. | 0.885 |
MAG0590 | secA | MAG0590 | MAG2730 | Conserved hypothetical protein. | Preprotein translocase SecA subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. | 0.954 |
MAG0590 | secD | MAG0590 | MAG2250 | Conserved hypothetical protein. | Protein export membrane protein. | 0.999 |
MAG0590 | secY | MAG0590 | MAG5260 | Conserved hypothetical protein. | Preprotein translocase SecY subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | 0.996 |
atpE | MAG0590 | MAG3510 | MAG0590 | ATP synthase C chain; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. | Conserved hypothetical protein. | 0.960 |
atpE | rpsE | MAG3510 | MAG5300 | ATP synthase C chain; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. | 30S ribosomal protein S5; With S4 and S12 plays an important role in translational accuracy; Belongs to the universal ribosomal protein uS5 family. | 0.798 |
atpE | secY | MAG3510 | MAG5260 | ATP synthase C chain; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. | Preprotein translocase SecY subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | 0.707 |
ffh | MAG0435 | MAG5820 | MAG0435 | Signal Recognition Particle Protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. | Hypothetical protein; Belongs to the SecE/SEC61-gamma family. | 0.900 |