| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MAG0660 | glyA | MAG0660 | MAG0700 | ATPase, AAA family. | Serine hydroxymethyltransferase (Serinemethylase) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.816 |
| MAG0660 | mucB | MAG0660 | MAG0740 | ATPase, AAA family. | DNA damage repair protein MucB; Belongs to the DNA polymerase type-Y family. | 0.781 |
| MAG0660 | nadD | MAG0660 | MAG0750 | ATPase, AAA family. | Bidomainal protein; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.753 |
| MAG0660 | nifS | MAG0660 | MAG0720 | ATPase, AAA family. | Nitrogen fixation protein NifS. | 0.780 |
| MAG0660 | nifU | MAG0660 | MAG0730 | ATPase, AAA family. | Nitrogen fixation protein NifU. | 0.715 |
| MAG0660 | pheS | MAG0660 | MAG0670 | ATPase, AAA family. | Phenylalanyl tRNA Synthetase alpha chain (PheS); Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. | 0.888 |
| MAG0660 | pheT | MAG0660 | MAG0690 | ATPase, AAA family. | Phenylalanyl tRNA synthetase beta chain (PheT); Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.832 |
| MAG0660 | pip | MAG0660 | MAG0710 | ATPase, AAA family. | Proline iminopeptidase (Pip); Belongs to the peptidase S33 family. | 0.763 |
| MAG0660 | ung | MAG0660 | MAG0680 | ATPase, AAA family. | Uracil DNA glycosylase (Ung); Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. | 0.826 |
| glyA | MAG0660 | MAG0700 | MAG0660 | Serine hydroxymethyltransferase (Serinemethylase) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | ATPase, AAA family. | 0.816 |
| glyA | mucB | MAG0700 | MAG0740 | Serine hydroxymethyltransferase (Serinemethylase) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | DNA damage repair protein MucB; Belongs to the DNA polymerase type-Y family. | 0.695 |
| glyA | nadD | MAG0700 | MAG0750 | Serine hydroxymethyltransferase (Serinemethylase) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Bidomainal protein; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.857 |
| glyA | nifS | MAG0700 | MAG0720 | Serine hydroxymethyltransferase (Serinemethylase) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Nitrogen fixation protein NifS. | 0.810 |
| glyA | nifU | MAG0700 | MAG0730 | Serine hydroxymethyltransferase (Serinemethylase) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Nitrogen fixation protein NifU. | 0.689 |
| glyA | pheS | MAG0700 | MAG0670 | Serine hydroxymethyltransferase (Serinemethylase) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Phenylalanyl tRNA Synthetase alpha chain (PheS); Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. | 0.866 |
| glyA | pheT | MAG0700 | MAG0690 | Serine hydroxymethyltransferase (Serinemethylase) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Phenylalanyl tRNA synthetase beta chain (PheT); Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.887 |
| glyA | pip | MAG0700 | MAG0710 | Serine hydroxymethyltransferase (Serinemethylase) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Proline iminopeptidase (Pip); Belongs to the peptidase S33 family. | 0.762 |
| glyA | ung | MAG0700 | MAG0680 | Serine hydroxymethyltransferase (Serinemethylase) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Uracil DNA glycosylase (Ung); Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. | 0.829 |
| mucB | MAG0660 | MAG0740 | MAG0660 | DNA damage repair protein MucB; Belongs to the DNA polymerase type-Y family. | ATPase, AAA family. | 0.781 |
| mucB | glyA | MAG0740 | MAG0700 | DNA damage repair protein MucB; Belongs to the DNA polymerase type-Y family. | Serine hydroxymethyltransferase (Serinemethylase) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.695 |