dnaK protein (Mycoplasma agalactiae PG2) - STRING interaction network

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Score

dnaK

Chaperone protein dnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. (598 aa)

Predicted Functional Partners:

grpE

0.999

clp

0.999

dnaJ

0.999

MAG2540

0.996

rplP

0.985

nifU

0.970

hrcA

0.966

eno

0.887

rpsB

0.884

rplJ

0.884

Your Current Organism:

Mycoplasma agalactiae PG2

NCBI taxonomy Id: 347257
Other names: M. agalactiae PG2, Mycoplasma agalactiae str. PG2, Mycoplasma agalactiae strain PG2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MAG2540	clp	MAG2540	MAG6240	Hypothetical protein, Vpma like, predictedlipoprotein.	ClpB; Belongs to the ClpA/ClpB family.	0.433
MAG2540	dnaJ	MAG2540	MAG7280	Hypothetical protein, Vpma like, predictedlipoprotein.	Heat shock protein DNAJ (activation of DNAK); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent intera [...]	0.971
MAG2540	dnaK	MAG2540	MAG1460	Hypothetical protein, Vpma like, predictedlipoprotein.	Chaperone protein dnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.996
clp	MAG2540	MAG6240	MAG2540	ClpB; Belongs to the ClpA/ClpB family.	Hypothetical protein, Vpma like, predictedlipoprotein.	0.433
clp	dnaJ	MAG6240	MAG7280	ClpB; Belongs to the ClpA/ClpB family.	Heat shock protein DNAJ (activation of DNAK); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent intera [...]	0.946
clp	dnaK	MAG6240	MAG1460	ClpB; Belongs to the ClpA/ClpB family.	Chaperone protein dnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.999
clp	grpE	MAG6240	MAG5580	ClpB; Belongs to the ClpA/ClpB family.	Heat shock protein GrpE (activation of DnaK); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. S [...]	0.926
clp	hrcA	MAG6240	MAG5590	ClpB; Belongs to the ClpA/ClpB family.	Heat inducible transcription repressor hrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons.	0.744
dnaJ	MAG2540	MAG7280	MAG2540	Heat shock protein DNAJ (activation of DNAK); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent intera [...]	Hypothetical protein, Vpma like, predictedlipoprotein.	0.971
dnaJ	clp	MAG7280	MAG6240	Heat shock protein DNAJ (activation of DNAK); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent intera [...]	ClpB; Belongs to the ClpA/ClpB family.	0.946
dnaJ	dnaK	MAG7280	MAG1460	Heat shock protein DNAJ (activation of DNAK); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent intera [...]	Chaperone protein dnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.999
dnaJ	grpE	MAG7280	MAG5580	Heat shock protein DNAJ (activation of DNAK); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent intera [...]	Heat shock protein GrpE (activation of DnaK); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. S [...]	0.978
dnaJ	hrcA	MAG7280	MAG5590	Heat shock protein DNAJ (activation of DNAK); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent intera [...]	Heat inducible transcription repressor hrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons.	0.729
dnaJ	rplP	MAG7280	MAG5390	Heat shock protein DNAJ (activation of DNAK); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent intera [...]	50S ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family.	0.915
dnaJ	rpsB	MAG7280	MAG2590	Heat shock protein DNAJ (activation of DNAK); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent intera [...]	30S ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family.	0.904
dnaK	MAG2540	MAG1460	MAG2540	Chaperone protein dnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	Hypothetical protein, Vpma like, predictedlipoprotein.	0.996
dnaK	clp	MAG1460	MAG6240	Chaperone protein dnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	ClpB; Belongs to the ClpA/ClpB family.	0.999
dnaK	dnaJ	MAG1460	MAG7280	Chaperone protein dnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	Heat shock protein DNAJ (activation of DNAK); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent intera [...]	0.999
dnaK	eno	MAG1460	MAG3190	Chaperone protein dnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.	0.887
dnaK	grpE	MAG1460	MAG5580	Chaperone protein dnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	Heat shock protein GrpE (activation of DnaK); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. S [...]	0.999