| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MAG5560 | mscL | MAG5560 | MAG5570 | Conserved hypothetical protein. | Large conductance mechanosensitive channel. | 0.535 |
| MAG5560 | rplU | MAG5560 | MAG5550 | Conserved hypothetical protein. | 50S ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. | 0.452 |
| grpE | hrcA | MAG5580 | MAG5590 | Heat shock protein GrpE (activation of DnaK); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. S [...] | Heat inducible transcription repressor hrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.994 |
| grpE | mscL | MAG5580 | MAG5570 | Heat shock protein GrpE (activation of DnaK); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. S [...] | Large conductance mechanosensitive channel. | 0.588 |
| grpE | polA | MAG5580 | MAG1650 | Heat shock protein GrpE (activation of DnaK); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. S [...] | DNA polymerase I: 5' 3' exonuclease domain. | 0.745 |
| grpE | rpmE | MAG5580 | MAG7490 | Heat shock protein GrpE (activation of DnaK); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. S [...] | 50S ribosomal protein L31; Belongs to the bacterial ribosomal protein bL31 family. | 0.545 |
| grpE | ybeY | MAG5580 | MAG1150 | Heat shock protein GrpE (activation of DnaK); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. S [...] | Conserved hypothetical protein; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. | 0.425 |
| hrcA | grpE | MAG5590 | MAG5580 | Heat inducible transcription repressor hrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | Heat shock protein GrpE (activation of DnaK); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. S [...] | 0.994 |
| hrcA | mscL | MAG5590 | MAG5570 | Heat inducible transcription repressor hrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | Large conductance mechanosensitive channel. | 0.469 |
| hrcA | rpmE | MAG5590 | MAG7490 | Heat inducible transcription repressor hrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 50S ribosomal protein L31; Belongs to the bacterial ribosomal protein bL31 family. | 0.557 |
| ktrA | ktrB | MAG3750 | MAG3760 | Potassium uptake protein KtrA. | Potassium uptake protein KtrB. | 0.999 |
| ktrA | metK | MAG3750 | MAG5800 | Potassium uptake protein KtrA. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.721 |
| ktrA | mscL | MAG3750 | MAG5570 | Potassium uptake protein KtrA. | Large conductance mechanosensitive channel. | 0.671 |
| ktrB | ktrA | MAG3760 | MAG3750 | Potassium uptake protein KtrB. | Potassium uptake protein KtrA. | 0.999 |
| ktrB | mscL | MAG3760 | MAG5570 | Potassium uptake protein KtrB. | Large conductance mechanosensitive channel. | 0.721 |
| metK | ktrA | MAG5800 | MAG3750 | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | Potassium uptake protein KtrA. | 0.721 |
| metK | mscL | MAG5800 | MAG5570 | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | Large conductance mechanosensitive channel. | 0.543 |
| metK | polA | MAG5800 | MAG1650 | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | DNA polymerase I: 5' 3' exonuclease domain. | 0.760 |
| mscL | MAG5560 | MAG5570 | MAG5560 | Large conductance mechanosensitive channel. | Conserved hypothetical protein. | 0.535 |
| mscL | grpE | MAG5570 | MAG5580 | Large conductance mechanosensitive channel. | Heat shock protein GrpE (activation of DnaK); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. S [...] | 0.588 |