| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| KRN94234.1 | KRN94860.1 | IV55_GL000583 | IV55_GL000401 | Deoxyuridine 5-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | ComE operon protein 2. | 0.955 |
| KRN94234.1 | ndk | IV55_GL000583 | IV55_GL001713 | Deoxyuridine 5-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Nucleoside diphosphate kinase; Belongs to the NDK family. | 0.972 |
| KRN94234.1 | nrdE | IV55_GL000583 | IV55_GL001076 | Deoxyuridine 5-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Ribonucleotide-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.847 |
| KRN94234.1 | nrdF | IV55_GL000583 | IV55_GL001075 | Deoxyuridine 5-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Ribonucleotide-diphosphate reductase subunit beta. | 0.495 |
| KRN94234.1 | tdk | IV55_GL000583 | IV55_GL001234 | Deoxyuridine 5-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Thymidine kinase. | 0.974 |
| KRN94234.1 | thyA | IV55_GL000583 | IV55_GL000889 | Deoxyuridine 5-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.985 |
| KRN94234.1 | tmk | IV55_GL000583 | IV55_GL001087 | Deoxyuridine 5-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.954 |
| KRN94860.1 | KRN94234.1 | IV55_GL000401 | IV55_GL000583 | ComE operon protein 2. | Deoxyuridine 5-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.955 |
| KRN94860.1 | tdk | IV55_GL000401 | IV55_GL001234 | ComE operon protein 2. | Thymidine kinase. | 0.945 |
| KRN94860.1 | thyA | IV55_GL000401 | IV55_GL000889 | ComE operon protein 2. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.950 |
| KRN94860.1 | tmk | IV55_GL000401 | IV55_GL001087 | ComE operon protein 2. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.945 |
| KRN96564.1 | holB | IV55_GL001081 | IV55_GL001089 | Hypothetical protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. | DNA polymerase III subunit delta. | 0.909 |
| KRN96564.1 | recR | IV55_GL001081 | IV55_GL001082 | Hypothetical protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. | Recombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. | 0.990 |
| KRN96564.1 | tmk | IV55_GL001081 | IV55_GL001087 | Hypothetical protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.881 |
| holB | KRN96564.1 | IV55_GL001089 | IV55_GL001081 | DNA polymerase III subunit delta. | Hypothetical protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. | 0.909 |
| holB | recR | IV55_GL001089 | IV55_GL001082 | DNA polymerase III subunit delta. | Recombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. | 0.911 |
| holB | tmk | IV55_GL001089 | IV55_GL001087 | DNA polymerase III subunit delta. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.933 |
| ndk | KRN94234.1 | IV55_GL001713 | IV55_GL000583 | Nucleoside diphosphate kinase; Belongs to the NDK family. | Deoxyuridine 5-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.972 |
| ndk | nrdE | IV55_GL001713 | IV55_GL001076 | Nucleoside diphosphate kinase; Belongs to the NDK family. | Ribonucleotide-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.968 |
| ndk | nrdF | IV55_GL001713 | IV55_GL001075 | Nucleoside diphosphate kinase; Belongs to the NDK family. | Ribonucleotide-diphosphate reductase subunit beta. | 0.967 |
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