KRN96214.1 protein (Lactobacillus siliginis)

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

KRN96214.1

pduC protein. (554 aa)

Predicted Functional Partners:

PduD

0.999

KRN96216.1

0.999

KRN96213.1

0.979

KRN96227.1

0.974

KRN96218.1

0.961

KRN96228.1

0.953

KRN96217.1

0.936

dhaT

0.927

adhE

0.927

KRN96226.1

0.887

Your Current Organism:

Lactobacillus siliginis

NCBI taxonomy Id: 348151
Other names: DSM 22696, JCM 16155, KCTC 3985, L. siliginis, Lactobacillus siliginis Aslam et al. 2006, NBRC 101315, strain M1-212

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KRN96213.1	KRN96214.1	IV55_GL001599	IV55_GL001600	Propanediol utilization protein PduB.	pduC protein.	0.979
KRN96213.1	KRN96216.1	IV55_GL001599	IV55_GL001602	Propanediol utilization protein PduB.	Propanediol dehydratase small subunit.	0.964
KRN96213.1	KRN96217.1	IV55_GL001599	IV55_GL001603	Propanediol utilization protein PduB.	Propanediol utilization ATPase.	0.916
KRN96213.1	KRN96218.1	IV55_GL001599	IV55_GL001604	Propanediol utilization protein PduB.	Hypothetical protein.	0.961
KRN96213.1	KRN96226.1	IV55_GL001599	IV55_GL001612	Propanediol utilization protein PduB.	ATP cob(I)alamin adenosyltransferase.	0.859
KRN96213.1	KRN96227.1	IV55_GL001599	IV55_GL001613	Propanediol utilization protein PduB.	Aldehyde dehydrogenase EutE.	0.846
KRN96213.1	PduD	IV55_GL001599	IV55_GL001601	Propanediol utilization protein PduB.	Propanediol dehydratase medium subunit.	0.971
KRN96213.1	adhE	IV55_GL001599	IV55_GL001463	Propanediol utilization protein PduB.	Bifunctional acetaldehyde-CoA alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.	0.525
KRN96214.1	KRN96213.1	IV55_GL001600	IV55_GL001599	pduC protein.	Propanediol utilization protein PduB.	0.979
KRN96214.1	KRN96216.1	IV55_GL001600	IV55_GL001602	pduC protein.	Propanediol dehydratase small subunit.	0.999
KRN96214.1	KRN96217.1	IV55_GL001600	IV55_GL001603	pduC protein.	Propanediol utilization ATPase.	0.936
KRN96214.1	KRN96218.1	IV55_GL001600	IV55_GL001604	pduC protein.	Hypothetical protein.	0.961
KRN96214.1	KRN96226.1	IV55_GL001600	IV55_GL001612	pduC protein.	ATP cob(I)alamin adenosyltransferase.	0.887
KRN96214.1	KRN96227.1	IV55_GL001600	IV55_GL001613	pduC protein.	Aldehyde dehydrogenase EutE.	0.974
KRN96214.1	KRN96228.1	IV55_GL001600	IV55_GL001614	pduC protein.	NADPH-dependent 1,3-propanediol dehydrogenase.	0.953
KRN96214.1	PduD	IV55_GL001600	IV55_GL001601	pduC protein.	Propanediol dehydratase medium subunit.	0.999
KRN96214.1	adhE	IV55_GL001600	IV55_GL001463	pduC protein.	Bifunctional acetaldehyde-CoA alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.	0.927
KRN96214.1	dhaT	IV55_GL001600	IV55_GL000194	pduC protein.	1,3-propanediol dehydrogenase.	0.927
KRN96216.1	KRN96213.1	IV55_GL001602	IV55_GL001599	Propanediol dehydratase small subunit.	Propanediol utilization protein PduB.	0.964
KRN96216.1	KRN96214.1	IV55_GL001602	IV55_GL001600	Propanediol dehydratase small subunit.	pduC protein.	0.999

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

52

average node degree:

9.45

avg. local clustering coefficient:

0.958

expected number of edges:

20

PPI enrichment p-value:

2.86e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007165

Signal transduction

6 of 62

1.51

1.91

6.21e-06

GO:0000160

Phosphorelay signal transduction system

5 of 52

1.51

1.66

5.65e-05

GO:0050794

Regulation of cellular process

9 of 253

1.08

1.24

2.38e-06

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004673

Protein histidine kinase activity

5 of 25

1.83

2.27

8.43e-06

GO:0000155

Phosphorelay sensor kinase activity

4 of 24

1.75

1.79

0.00011

GO:0016772

Transferase activity, transferring phosphorus-containing groups

7 of 171

1.14

1.22

2.82e-05

GO:0016740

Transferase activity

9 of 591

0.71

0.61

0.00028

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005886

Plasma membrane

7 of 579

0.61

0.36

0.0471

GO:0016021

Integral component of membrane

8 of 769

0.54

0.33

0.0471

GO:0016020

Membrane

9 of 1176

0.41

0.28

0.0471

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2148

Phosphorelay signal transduction system, and RNA polymerase sigma factor 54 interaction domain

11 of 41

1.96

6.07

1.09e-18

CL:2155

Mixed, incl. PAS domain, and Phosphoric diester hydrolase activity

8 of 21

2.11

5.5

6.46e-14

CL:2161

PAS-associated, C-terminal, and Bacterial chemotaxis

6 of 10

2.31

4.88

6.39e-11

CL:2163

Diguanylate cyclase, and Regulation of signaling

3 of 5

2.31

2.21

5.90e-05

CL:2215

Sigma-54 interaction domain, ATP-binding site 1, and PAS fold

3 of 7

2.16

2.01

0.00012

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

10 of 277

1.08

1.42

8.29e-09

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0418

Kinase

4 of 74

1.26

0.79

0.0122

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001610

PAC motif

4 of 8

2.23

2.3

3.24e-05

IPR035965

PAS domain superfamily

4 of 10

2.13

2.26

3.27e-05

IPR000014

PAS domain

4 of 10

2.13

2.26

3.27e-05

IPR004358

Signal transduction histidine kinase-related protein, C-terminal

4 of 17

1.9

1.92

9.67e-05

IPR005467

Histidine kinase domain

4 of 20

1.83

1.81

0.00014

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00086

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)

4 of 9

2.17

2.71

3.74e-06

SM00091

PAS domain

4 of 11

2.09

2.64

3.74e-06

SM00388

His Kinase A (phosphoacceptor) domain

4 of 17

1.9

2.31

1.03e-05

SM00387

Histidine kinase-like ATPases

4 of 22

1.79

2.1

1.92e-05

SM00065

Domain present in phytochromes and cGMP-specific phosphodiesterases.

2 of 5

2.13

1.25

0.0042

(more ...)

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