Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
nosNitric-oxide synthase; Catalyzes the production of nitric oxide. Belongs to the NOS family. Bacterial NOS oxygenase subfamily. (378 aa)    
Predicted Functional Partners:
NP_0200A
Peptidase M20 family protein (homolog to succinyl-diaminopimelate desuccinylase).
     
  0.900
pdaD
Pyruvoyl-dependent arginine decarboxylase.
     
  0.900
argG
Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily.
     
  0.900
argH
Argininosuccinate lyase.
     
  0.900
argF
Ornithine carbamoyltransferase.
     
  0.900
citZ
Citrate synthase; Unknown EC_number=2.3.3.16.
      
 0.618
gyrB
DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
      
 0.618
sod
Superoxide dismutase (Mn); Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.
      
 0.618
pyrE
Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
      
 0.559
NP_1910A
Uncharacterized protein.
       0.534
Your Current Organism:
Natronomonas pharaonis
NCBI taxonomy Id: 348780
Other names: N. pharaonis DSM 2160, Natronomonas pharaonis ATCC 35678, Natronomonas pharaonis DSM 2160, Natronomonas pharaonis Gabara, Natronomonas pharaonis JCM 8858, Natronomonas pharaonis str. DSM 2160, Natronomonas pharaonis strain DSM 2160
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