node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
apt1 | apt2 | NP_1426A | NP_1254A | HGPRTase-like protein; May catalyze a purine salvage reaction, the substrate is unknown. | Purine phosphoribosyltransferase (adenine phosphoribosyltransferase, xanthine-guanine phosphoribosyltransferase). | 0.900 |
apt1 | guaAa1 | NP_1426A | NP_0620A | HGPRTase-like protein; May catalyze a purine salvage reaction, the substrate is unknown. | GMP synthase (glutamine-hydrolyzing) subunit A; Catalyzes the synthesis of GMP from XMP. | 0.933 |
apt1 | guaAa4 | NP_1426A | NP_2928A | HGPRTase-like protein; May catalyze a purine salvage reaction, the substrate is unknown. | Glutamine amidotransferase (homolog to GMP synthase subunit A). | 0.933 |
apt1 | guaAb | NP_1426A | NP_1970A | HGPRTase-like protein; May catalyze a purine salvage reaction, the substrate is unknown. | GMP synthase (glutamine-hydrolyzing) subunit B; Catalyzes the synthesis of GMP from XMP. | 0.978 |
apt1 | purL | NP_1426A | NP_2982A | HGPRTase-like protein; May catalyze a purine salvage reaction, the substrate is unknown. | Phosphoribosylformylglycinamidine synthase subunit PurL; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] | 0.541 |
apt1 | pyrG | NP_1426A | NP_1968A | HGPRTase-like protein; May catalyze a purine salvage reaction, the substrate is unknown. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.583 |
apt1 | surE | NP_1426A | NP_4208A | HGPRTase-like protein; May catalyze a purine salvage reaction, the substrate is unknown. | 5'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.929 |
apt2 | apt1 | NP_1254A | NP_1426A | Purine phosphoribosyltransferase (adenine phosphoribosyltransferase, xanthine-guanine phosphoribosyltransferase). | HGPRTase-like protein; May catalyze a purine salvage reaction, the substrate is unknown. | 0.900 |
apt2 | guaAa1 | NP_1254A | NP_0620A | Purine phosphoribosyltransferase (adenine phosphoribosyltransferase, xanthine-guanine phosphoribosyltransferase). | GMP synthase (glutamine-hydrolyzing) subunit A; Catalyzes the synthesis of GMP from XMP. | 0.933 |
apt2 | guaAa4 | NP_1254A | NP_2928A | Purine phosphoribosyltransferase (adenine phosphoribosyltransferase, xanthine-guanine phosphoribosyltransferase). | Glutamine amidotransferase (homolog to GMP synthase subunit A). | 0.943 |
apt2 | guaAb | NP_1254A | NP_1970A | Purine phosphoribosyltransferase (adenine phosphoribosyltransferase, xanthine-guanine phosphoribosyltransferase). | GMP synthase (glutamine-hydrolyzing) subunit B; Catalyzes the synthesis of GMP from XMP. | 0.978 |
apt2 | purL | NP_1254A | NP_2982A | Purine phosphoribosyltransferase (adenine phosphoribosyltransferase, xanthine-guanine phosphoribosyltransferase). | Phosphoribosylformylglycinamidine synthase subunit PurL; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] | 0.541 |
apt2 | pyrG | NP_1254A | NP_1968A | Purine phosphoribosyltransferase (adenine phosphoribosyltransferase, xanthine-guanine phosphoribosyltransferase). | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.583 |
apt2 | surE | NP_1254A | NP_4208A | Purine phosphoribosyltransferase (adenine phosphoribosyltransferase, xanthine-guanine phosphoribosyltransferase). | 5'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.919 |
guaAa1 | apt1 | NP_0620A | NP_1426A | GMP synthase (glutamine-hydrolyzing) subunit A; Catalyzes the synthesis of GMP from XMP. | HGPRTase-like protein; May catalyze a purine salvage reaction, the substrate is unknown. | 0.933 |
guaAa1 | apt2 | NP_0620A | NP_1254A | GMP synthase (glutamine-hydrolyzing) subunit A; Catalyzes the synthesis of GMP from XMP. | Purine phosphoribosyltransferase (adenine phosphoribosyltransferase, xanthine-guanine phosphoribosyltransferase). | 0.933 |
guaAa1 | guaAa4 | NP_0620A | NP_2928A | GMP synthase (glutamine-hydrolyzing) subunit A; Catalyzes the synthesis of GMP from XMP. | Glutamine amidotransferase (homolog to GMP synthase subunit A). | 0.917 |
guaAa1 | guaAb | NP_0620A | NP_1970A | GMP synthase (glutamine-hydrolyzing) subunit A; Catalyzes the synthesis of GMP from XMP. | GMP synthase (glutamine-hydrolyzing) subunit B; Catalyzes the synthesis of GMP from XMP. | 0.998 |
guaAa1 | guaB1 | NP_0620A | NP_3384A | GMP synthase (glutamine-hydrolyzing) subunit A; Catalyzes the synthesis of GMP from XMP. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.978 |
guaAa1 | guaB2 | NP_0620A | NP_3080A | GMP synthase (glutamine-hydrolyzing) subunit A; Catalyzes the synthesis of GMP from XMP. | Inosine-5'-monophosphate dehydrogenase. | 0.981 |